61448-77-9

Upstream product

• 1072-72-6 Tetrahydrothiopyran-4-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 61448-81-5 3,5-bis-((Ξ)-4-methoxy-benzylidene)-1,1-dioxo-tetrahydro-1λ⁶-thiopyran-4-one 
• 69559-20-2 C₂₄H₂₄N₂O₂S₂ 
• 61479-64-9 7-((Z)-4-methoxy-benzylidene)-3-(4-methoxy-phenyl)-2-propyl-2,3,3a,4,6,7-hexahydro-thiopyrano[4,3-c]pyrazole 
• 83319-88-4 7-((Z)-4-methoxy-benzylidene)-3-(4-methoxy-phenyl)-1-propyl-1,4,6,7-tetrahydro-thiopyrano[4,3-c]pyrazole 
• 62040-89-5 3-(4-Methoxy-phenyl)-7-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-2-[3-(4-methyl-piperazin-1-yl)-propyl]-2,3,3a,4,6,7-hexahydro-thiopyrano[4,3-c]pyrazole 
• 61448-79-1 3,5-Bis-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-1-oxo-tetrahydro-1λ⁴-thiopyran-4-one 
• 61448-81-5 (3Z,5Z)-3,5-bis[(4-methoxyphenyl)methylene]tetrahydro-4H-thiopyran-4-one 1,1-dioxide 
• 61448-64-4 3-(4-Methoxy-phenyl)-7-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-2-propyl-2,3,3a,4,6,7-hexahydro-thiopyrano[4,3-c]pyrazole 5-oxide 
• 61448-66-6 3-(4-Methoxy-phenyl)-7-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-2-propyl-2,3,3a,4,6,7-hexahydro-thiopyrano[4,3-c]pyrazole 5,5-dioxide 
• 62121-51-1 3-(4-Methoxy-phenyl)-7-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-2-[3-(4-methyl-piperazin-1-yl)-propyl]-2,3,3a,4,6,7-hexahydro-thiopyrano[4,3-c]pyrazole 5,5-dioxide 

Relevant academic research and scientific papers

An efficient and improved method for the synthesis of bis(arylmethylidene) thiopyranones

Double crossed aldol condensation of a variety of aromatic aldehydes with tetrahydrothiopyran-4-one in the presence of N-(trimethylsilyl)diethylamine and 5 M lithium perchlorate in diethyl ether at room temperature is described. Excellent yields of 3,5-bi

Synthesis of bis(arylmethylidene)thiopyranones and crystal structure of the phenyl derivative

A convenient method is offered for double aldol condensation of tetrahydrothiopyran-4-one with aromatic aldehydes under LiBr catalysis. An X-ray analysis verifies the proposed structures. Copyright Taylor & Francis Group, LLC.

New MD2 inhibitors derived from curcumin with improved anti-inflammatory activity

An overactive Toll-like receptor (TLR) signaling complex is a significant pathogenic factor of acute and chronic inflammatory diseases. The natural product curcumin is reported to inhibit the TLR4 co-receptor, MD2 (myeloid differentiation protein 2), but

A convenient one-pot synthesis of thiopyrano[4,3-b]pyran derivatives under LiOH·H2O/EtOH/ultrasonic conditions

Various derivatives of thiopyrano[4,3-b]pyran structure are synthesized via a multicomponent procedure starting from tetrahydro-4H-thiopyran-4-one, aromatic aldehydes, and malononitrile. Reactions take place by the use of catalytic quantities of LiOH·Hsu

Green chemistry preparation of MgO nanopowders: efficient catalyst for the synthesis of thiochromeno[4,3-b]pyran and thiopyrano[4,3-b]pyran derivatives

A mild and efficient method for the synthesis of thiochro meno[4,3-b]pyran and thiopyrano[4,3-b]pyran derivatives using MgO nanopowders as a catalyst is described. The MgO nanopowders were prepared via a green biosynthesis method using an extract of Rosma

Synthesis and evaluation of curcumin-related compounds for anticancer activity

Sixty-one curcumin-related compounds were synthesized and evaluated for their anticancer activity toward cultured prostate cancer PC-3 cells, pancreas cancer Panc-1 cells and colon cancer HT-29 cells. Inhibitory effects of these compounds on the growth of PC-3, Panc-1 and HT-29 cells were determined by the MTT assay. Compounds E10, F10, FN1 and FN2 exhibited exceptionally potent inhibitory effects on the growth of cultured PC-3, Panc-1 and HT-29 cells. The IC50 for these compounds was lower than 1 μM in all three cell lines. E10 was 72-, 46- and 117-fold more active than curcumin for inhibiting the growth of PC-3, Panc-1 and HT-29 cells, respectively. F10 was 69-, 34- and 72-fold more active than curcumin for inhibiting the growth of PC-3, Panc-1 and HT-29 cells, respectively. FN1 and FN2 had about the same inhibitory effect as E10 and F10 toward Panc-1 cells but were less active than E10 and F10 toward PC-3 and HT-29 cells. The active compounds were potent stimulators of apoptosis. The present study indicates that E10, F10, FN1 and FN2 may have useful anticancer activity.

CURCUMIN ANALOGS AND METHODS OF USE THEREOF

Curcumin analogs and methods of use thereof are provided.

The synthesis of highly functionalised pyridines using Ghosez-type reactions of dihydropyrazoles

The aza-Diels-Alder reaction of αβ-unsaturated hydrazones is a general methodology that has been applied both to the synthesis of natural products and to the development of multicomponent reactions. Trends have emerged as to the effect of substituents on the efficiency of this reaction with substituents at the C2 and C4-positions of the aza-diene in general suppressing the reaction. Here we report that 4,5-dihydropyrazoles can function as substrates in this process despite the presence of substituents at both of these positions. A one pot, four chemical step sequence carried out under standard thermal or microwave conditions results in the formation of the corresponding pyridine-containing compounds. The scope of the reaction is explored and additional insights into the proposed mechanism of this reaction are provided.

A highly efficient method for solvent-free synthesis of bisarylmethylidenes of pyranones and thiopyranones

A remarkable efficient double crossed aldol condensation of heterocyclic ketones with a variety of aromatic aldehydes is described at room temperature in the presence of magnesium bromide ethyl etherate, triethylamine, and methanol under solvent-free cond

Synthesis and antiinflammatory activity of hexahydrothiopyrano[4,3-c]pyrazoles and related analogues

A series of novel hexahydrothiopyrano[4,3-c]pyrazoles and related analogues were prepared and tested for antiinflammatory activity by using the mouse active Arthus reaction and the delayed hypersensitivity skin reaction in guinea pigs as primary screens.