6145-41-1

Usage

Uses

Used in Agricultural Applications:
3-Chlorophenylguanidine is used as a fungicide and bactericide for protecting crops from microbial infections, thereby ensuring higher yields and crop quality. Its application helps in reducing the spread of diseases that can be detrimental to plant health.
Used in Industrial Applications:
In industrial settings, 3-Chlorophenylguanidine serves as a biocidal agent in various products, such as paints, coatings, and wood preservatives, to prevent the growth of fungi and bacteria that can cause decay and spoilage.
Given its toxic nature to aquatic life and its classification as a hazardous substance, it is crucial to employ 3-Chlorophenylguanidine responsibly, adhering to safety standards and regulations to minimize its impact on the environment and human health. Proper protective equipment should be worn when handling this chemical to avoid skin and eye irritation, as well as respiratory distress that can arise from exposure to high concentrations.

InChI:InChI=1/C7H8ClN3/c8-5-2-1-3-6(4-5)11-7(9)10/h1-4H,(H4,9,10,11)

Upstream product

• 420-04-2 CYANAMID 
• 141-85-5 3-chloroaniline hydrochloride 
• 108-42-9 3-chloro-aniline 

Downstream Products

• 112676-08-1 N-(3-chlorophenyl)-4-(3-pyridyl)-2-pyrimidinamine 
• 468084-58-4 (3-Chlorophenyl)-(4[3,5-dimethoxy-4-(2-morpholin-4-yl-ethoxy)phenyl]pyrimidin-2-yl)-amine 
• 1415509-22-6 C₁₈H₁₄ClN₅ 
• 56721-64-3 N-(3-chlorophenyl)-1H-benzo[d]imidazol-2-amine 
• 164658-40-6 (3-chloro-phenyl)-[4-(2-chloro-pyridin-4-yl)-pyrimidin-2-yl]-amine 
• 1383775-75-4 ethyl 2-((3-chlorophenyl)amino)-5,6,7,8-tetrahydroquinazoline-6-carboxylate 
• 1383775-77-6 tert-butyl 2-((3-chlorophenyl)amino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate 
• 403791-01-5 2-(3-Chloroanilino)-4-(2-methylimidazol-5-yl)pyrimidin 
• 403791-07-1 4-(1-Benzyl-2-methylimidazol-5-yl)-2-(3-chloroanilino)pyrimidine 

Relevant academic research and scientific papers

Identification of pyrimidine derivatives as hSMG-1 inhibitors

hSMG-1 kinase plays a dual role in a highly conserved RNA surveillance pathway termed nonsense-mediated RNA decay (NMD) and in cellular genotoxic stress response. Since deregulation of cellular responses to stress contributes to tumor growth and resistance to chemotherapy, hSMG-1 is a potential target for cancer treatment. From our screening efforts, we have identified pyrimidine derivatives as hSMG-1 kinase inhibitors. We report structure-based optimization of this pan-kinase scaffold to improve its biochemical profile and overall kinome selectivity, including mTOR and CDK, to generate the first reported selective hSMG-1 tool compound.

PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS

Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.