6147-96-2Relevant academic research and scientific papers
Naphthofuranone Derivatives as Specific Inhibitors of Thymidylate Synthases
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Page/Page column 5, (2010/03/31)
Synthetic compounds of 1,2-naphthalein moelcules (I) having specific inhibitory properties of the enzymatic activity of thymidylate synthases of bacterial species, their preparation, their pharmaceutical composition and use in the treatment and prophylaxi
NAPHTHOFURANONE DERIVATIVES AS SPECIFIC INHIBITORS OF THYMIDYLATE SYNTHASES
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Page/Page column 10-11, (2008/06/13)
Synthetic compounds of 1, 2 -naphthalein molecules (I) having specific inhibitory properties of the enzymatic activity of thymidylate synthases of bacterial species, their preparation, their pharmaceutical composition and use in the treatment and prophyla
Antibacterial agent discovery using thymidylate synthase biolibrary screening
Costi, M. Paola,Gelain, Arianna,Barlocco, Daniela,Ghelli, Stefano,Soragni, Fabrizia,Reniero, Fabiano,Rossi, Tiziana,Ruberto, Antonio,Guillou, Claude,Cavazzuti, Antonio,Casolari, Chiara,Ferrari, Stefania
, p. 5958 - 5968 (2007/10/03)
Thymidylate synthase (TS, Thy A) catalyzes the reductive methylation of 2′-deoxyuridine 5′-monophosphate to 2′-deoxythymidine 5′-monophosphate, an essential precursor for DNA synthesis. A specific inhibition of this enzyme induces bacterial cell death. As
