614729-70-3

Usage

Uses

Used in Pharmaceutical Industry:
(3-fluorothiophen-2-yl)methanol is used as a building block for the synthesis of pharmaceutical compounds due to its unique chemical structure and potential biological activities.
Used in Agrochemical Industry:
(3-fluorothiophen-2-yl)methanol is used as a precursor in the development of agrochemicals, contributing to the creation of new pesticides or other agricultural products.
Used in Organic Synthesis:
(3-fluorothiophen-2-yl)methanol is used as a reagent or intermediate in the synthesis of various organic compounds, leveraging its distinct functional groups for chemical reactions.
Used in Material Production:
(3-fluorothiophen-2-yl)methanol is used as a component in the production of new materials and chemical products, potentially enhancing their properties or performance.
Used in Medicinal Chemistry Research:
(3-fluorothiophen-2-yl)methanol is used as a subject of interest in medicinal chemistry research, exploring its potential therapeutic effects and biological activities for future drug development.

Upstream product

• 100421-52-1 methyl 3-fluorothiophene-2-carboxylate 
• 527-72-0 2-thiophenylcarboxylic acid 
• 32431-84-8 3-fluoro-2-thiophenecarboxylic acid 
• 32431-83-7 3-fluorothiophene-2-carbaldehyde 

Downstream Products

• 32431-83-7 3-fluorothiophene-2-carbaldehyde 

Relevant academic research and scientific papers

GLP-1 receptor agonists

The invention belongs to the technical field of medicine. In particular, the invention relates to a compound capable of being used as a GLP-1 receptor agonist, a pharmaceutically acceptable salt or a stereoisomer of the compound, a pharmaceutical composition and a preparation containing the compound, the pharmaceutically acceptable salt or the stereoisomer of the compound, and application of the compound, the pharmaceutically acceptable salt or the stereoisomer of the compound.

OXADIAZOLYLTHIOPHENE DERIVATIVES USEFUL AS HISTONE DEACETYLASE INHIBITORS

A compound of Formula I : (I) or a pharmaceutically acceptable salt thereof, wherein: each R' is QR1; each Q is independently selected from a bond, -C1-C10 alkylene, -C2-C10 alkenylene, -C(O)-, -C(O)O-, -C(O)N(R1)-, -C(O)N(R1)SO2- -N(R1)C(O)-, - N(R1)-, -N(SO2(R1)), -N(R1)SO2- -C(O)NR4R5-, -N(R4R5)C(O)-, -N(R4R5)- - S-, -SO-, -SO2-, -S(O)O-, -SO2N(R1)- and -O-; each R1 is independently selected from H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C10 haloalkyl, C1-C10 heteroalkyl, aryl, heteroaryl, C3-C10 cycloalkyl, -(C1-C10 alkylene)-C3-C10 cycloalkyl, halogen, cyano, C1-C10 alkylene- aryl, C1-C10 alkylene heteroaryl, C1-C10 heterocycloalkyl and -(C1-C10 alkylene)- C1-C10 heterocycloalkyl. The compounds are inhibitors of HDAC and therefore have potential utility in the therapy of a number of conditions including cancer and inflammation.

Fluorinated Dithienylethene-Naphthalenediimide Copolymers for High-Mobility n-Channel Field-Effect Transistors

We develop two donor-acceptor copolymers based on a fluorinated dithienylethene building block, namely PNFDTE1 and PNFDTE2, in which naphthalenediimide (NDI) acts as an acceptor unit. Thermogravimetric analysis displayed both copolymers having good thermal stability with high decomposition temperatures over 400 °C. Broad absorption spectra were observed in the UV-vis-NIR region, with the absorption maxima being 720 and 724 nm for PNFDTE1 and PNFDTE2, respectively. Cyclic voltammetry tests exhibited deep-lying lowest unoccupied molecular orbital energy levels of ca. -4.0 eV. Two-dimensional grazing incidence X-ray diffraction patterns showed that different packing modes for two polymers result in the variation in charge transport properties. Backbone fluorination effectively decreases electron injection barrier, thereby facilitating electron mobility. An impressive electron mobility of 3.20 cm2 V-1 s-1 was achieved in air for PNFDTE1-based polymer field-effect transistors fabricated on the poly(ethylene terephthalate) substrate. The mobility value is almost the highest for NDI-containing polymers on the flexible substrate. This work provides a guideline for design and synthesis of fluorinated semiconductors that enables control of charge-transport polarity.

HETEROARYL-SUBSTITUTED PYRAZOLOPYRIDINES AND USE THEREOF AS SOLUBLE GUANYLATE CYCLASE STIMULATORS

The present application relates to novel heteroaryl-substituted pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for t

CATHEPSIN CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF VARIOUS DISEASES

The present invention relates to compounds capable of inhibiting and/or decreasing the activity of one or more cathepsins, thereby treating and/or preventing various disease states associated with one or more cysteine proteases including, but not limited

TRIAZOLE DERIVATIVE OR SALT THEREOF

[Problem] To provide a compound which may be used in treating diseases in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is concerned, especially diabetes and insulin resistance. [Means for Solution] It was found that a triazole derivative or a pharmaceutically acceptable salt thereof, in which the 3-position of triazole ring is substituted with a trisubstituted methyl group and the 5-position is substituted with a lower alkyl, cycloalkyl or the like, has a strong 11β-HSD1-inhibitory activity. In addition, since the triazole derivative of the present invention shows excellent blood glucose-lowering action, it may be used in the treatment of diabetes and insulin resistance.

Nitrogen containing heterocyclic compounds and medicines containing the same

Compounds represented by the following general formula: (wherein X1, X2, X3 and X4 each independently represent a single bond, C1-6 alkylene, etc.; A2 represents optionally substituted phenyl, etc.; A1 represents an optionally substituted 5- to 7-membered heterocyclic group containing —C(═Q1)— (wherein Q1 represents oxygen, sulfur or ═N—R11 (wherein R11 represents hydrogen or C1-6 alkyl)) and nitrogen, etc.; and Z1 represents piperidin-diyl, etc.), salts thereof and hydrates of the foregoing.