614735-52-3

Upstream product

• 614735-35-2 4,4-dibromo-2-(4-methoxybenzyl)-10-methyl-3,4-dihydro-2H,10H-azepino[3,4-b]indole-1,5-dione 
• 614735-34-1 2-(4-methoxybenzyl)-10-methyl-1,2,3,4,5,10-hexahydroazepino[3,4-b]indole-1,5-dione 
• 7486-35-3 tri-n-butyl(vinyl)tin 
• 614735-37-4 4-bromo-2-(4-methoxybenzyl)-10-methyl-2H,10H-azepino[3,4-b]indole-1,5-dione 

Relevant academic research and scientific papers

Synthesis of 4-substituted azepino[3,4-b]indole-1,5-diones

Mono- or dibromo derivatives 2 and 3 were prepared by an efficient two-step route from 10-methyl-azepino[3,4-b]indole-1,5-dione 1. Elimination reaction on 2 gave access to 4-bromo-10-methyl-2H,10H-azepino[3,4-b]indole-1,5-diones 4. Finally, 4-substituted 10-methyl-2H,10H-azepino[3,4-b]indole-1,5-diones 6-14 were synthesised in good yields from 4 via palladium-mediated cross-coupling reactions.