61486-91-7

Basic information

• Product Name: 12,13-de-epoxy-12,13-didehydrorosamicin 20-dimethyl acetal
• Synonyms: 12,13-de-epoxy-12,13-didehydrorosamicin 20-dimethyl acetal
• CAS NO: 61486-91-7
• Molecular Weight: 611.817
• Mol File: 61486-91-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 12,13-de-epoxy-12,13-didehydrorosamicin 20-dimethyl acetal(CAS DataBase Reference)
• NIST Chemistry Reference: 12,13-de-epoxy-12,13-didehydrorosamicin 20-dimethyl acetal(61486-91-7)
• EPA Substance Registry System: 12,13-de-epoxy-12,13-didehydrorosamicin 20-dimethyl acetal(61486-91-7)

Safety Data

• Hazardous Substances Data: 61486-91-7(Hazardous Substances Data)

Upstream product

• 102438-11-9 rosaramicin N-oxide 
• 35834-26-5 rosaramicin 

Downstream Products

• 35834-26-5 rosaramicin 
• 56689-42-0 12,13-de-epoxy-12,13-didehydrorosaramicin 

Relevant articles and documents

Semisynthetic Macrolide Antibacterials Derived from Tylosin. Synthesis of 3-O-Acetyl-23-O-demycinosyl-4''-O-isovaleryltylosin and Related Compounds, as well as the 12,13-Epoxy Derivatives

Selective acylation techniques have been developed that enable the synthesis of 3-O-acetyl-4''-O-isovaleryltylosin and 3-O-acetyl-23-O-demycinosyl-4''-O-isovaleryltylosin to be carried out in an efficient manner starting from tylosin.The syntheses of the 2'-O-acetyl, 23-O-acetyl, and 2',23-di-O-acetyl derivatives of the latter are also described.The synthesis of key hydrazones is also described.The regio- and stereo-selective epoxidation of tylosin and its acyl derivatives afforded the 12,13-epoxyanalogues, which were used to synthesize novel acylated 12,13-epoxy derivatives of 23-O-demycinosyltylosin.