61494-16-4Relevant academic research and scientific papers
Copper-Catalyzed 1,6-Hydrodifluoroacetylation of para-Quinone Methides at Ambient Temperature with Bis(pinacolato)diboron as Reductant
Ke, Miaolin,Song, Qiuling
supporting information, p. 384 - 389 (2017/02/10)
An original and efficient copper-catalyzed 1,6-hydrodifluoroacetylation of para-quinone methides with difluoroalkyl bromides has been described with bis(pinacolato)diboron (B2pin2) as reductant. In this reaction, a new C(sp3)–CF2bond is constructed under smart conditions. A broad substrate scope of para-quinone methides (p-QMs) make this protocol very practical and attractive. Preliminary mechanistic studies manifested that a difluoroalkyl radical pathway was involved in this reaction. Also the presence of the diboron reagent was an essential requisite in this transformation. (Figure presented.).
Mannich Bases, XXI: Exchange Reactions of Phenolic Mannich Bases
Moehrle, Hans,Miller, Christoph
, p. 229 - 236 (2007/10/02)
Various p-substituted phenolic Mannich bases (and to a minor degree o-substituted derivatives) form alcohols and ethers when heated in aqueous alcohols in the presence of Na2EDTA or acetic acid.The reaction proceeds with amine elimination and subsequent addition of the solvent to the resulting quinone methide.
