615-78-1Relevant academic research and scientific papers
Straightforward pyrimidine ring construction: A versatile tool for the synthesis of nucleobase and nucleoside analogues
Robin, Aelig,Julienne, Karine,Meslin, Jean-Claude,Deniaud, David
, p. 634 - 643 (2007/10/03)
A general route to 1,2,4-trisubstituted pyrimidines is described in one to three steps from a common key precursor, diazadienium iodide 2. An efficient preliminary [4+2] cyclocondensation reaction between the azabutadiene building block 2 and various iso(thio)cyanates constitutes an original construction of the pyrimidine skeleton. Subsequent structural modifications on the heterocycle allow the elaboration of a 1-substituted pyrimidine library that includes nucleoside analogues. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
An efficient synthesis of 1-substituted uracil ring systems and their thio analogues
Robin, Aélig,Julienne, Karine,Raimbault, Sophie,Meslin, Jean-Claude,Deniaud, David
, p. 2805 - 2807 (2007/10/03)
A facile and simple regioselective synthesis of uracils and their thio analogues has been achieved by cyclocondensation of a common precursor, diazadienium iodide 1, and isothiocyanates 2a,b. The key step in this synthetic process is the preparation of 4-
NOVEL RING TRANSFORMATION REACTIONS AND THEIR APPLICATIONS TO THE SYNTHESES OF POTENTIAL ANTICANCER HETEROCYCLIC COMPOUNDS
Watanabe, K. A.,Su, T.-L.,Pankiewicz, K. W.,Harada, K.
, p. 289 - 307 (2007/10/02)
Novel heterocyclic ring trasformation reactions developed recently in our laboratory are described.They include pyrimidine to pyrimidine, pyrimidine to pyridine transformations.Also discussed are novel one-step procedures for conversion of 1,3-dimethyluracil derivatives into the pyridopyrimidine system.Some applications of these novel reactions to the syntheses of compounds of biological interest are also described.
