6152-90-5

Usage

Uses

Used in Pharmaceutical Industry:
(R)-HAVA is used as a therapeutic agent for neurological disorders due to its potential as a GABA analogue and its ability to modulate GABAergic neurotransmission.
Used in Antimicrobial Applications:
(R)-HAVA is used as an antimicrobial agent for its antifungal and antibacterial activities, making it a candidate for the development of new antimicrobial agents.
Used in Research and Development:
(R)-HAVA is used as a compound in the research and development of new pharmaceuticals and treatments, particularly in the areas of neurological disorders and infectious diseases.

Upstream product

• 6461-04-7 (R)-2-amino-5-methoxy-5-oxopentanoic acid 

Relevant academic research and scientific papers

Micropeptins from the freshwater cyanobacterium Microcystis aeruginosa (NIES-100)

Micropeptins C (1), D (2), E (3), and F (4) have been isolated from the freshwater cyanobacterium Microcystis aeruginosa (NIES-100). The structures were elucidated by analyses of MS, NMR spectra, and chemical degradation. Micropeptins C, D, E, and F inhib

Biosynthesis of 4-methylproline in cyanobacteria: Cloning of nosE and nosF genes and biochemical characterization of the encoded dehydrogenase and reductase activities

The biosynthesis of the unusual amino acid 4-methylproline in the Nostoc genus of cyanobacteria was investigated on the genetic and enzymatic level. Two genes involved in the biosynthesis were cloned and the corresponding enzymes, a zinc-dependent long-chain dehydrogenase and a Δ1-pyrroline-5-carboxylic acid (P5C) reductase homologue, were overexpressed in Escherichia coli and biochemically characterized. Putative substrates were synthesized to test enzyme substrate specificities, and deuterium labeling studies were carried out to reveal the stereospecificities of the enzymatic reactions with respect to the substrates as well as to the coenzymes.