61530-86-7Relevant academic research and scientific papers
Total Synthesis of Dinordrin and 18-Homodinordrin
Crabbe, Pierre,Bieber, Lothar,Nassim, Bahman
, p. 472 - 473 (1980)
A short and flexible synthetic route to A:B-trans A-norsteroids is described.
Construction of key building blocks towards the synthesis of cortistatins
Indu, Satrajit,Kaliappan, Krishna P.,Telore, Rahul D.
supporting information, p. 2432 - 2446 (2020/04/22)
This work reports the construction of key building blocks towards the synthesis of cortistatins; a family of steroidal alkaloids. Cortistatin A, being a primary target due to its superior biological properties over other congeners, has been prepared by two different synthetic routes. Synthesis of the precursor to the heavily substituted A-ring starting from d-glucose and construction of the DE-ring junction employing a Hajos-Parrish ketone as a chiral pool have been demonstrated. Efforts are underway to assemble these key fragments and build towards the total synthesis of cortistatin A.
Total Synthesis of Dinordrin and Analogues
Nassim, Bahman,Schlemper, Elmer O.,Crabbe, Pierre
, p. 2337 - 2347 (2007/10/02)
A total synthesis of optically active dinordrin (3c) is detailed, following a flexible and stereoselective route.A number of unexpected and potentially useful by-products have been identified.The preparation of the novel A-nor-steroid analogues (19), (20)
