61530-85-6

Upstream product

• 50-00-0 formaldehyd 
• 17553-86-5 (S)-Halos-Parish ketone 
• 618-41-7 Benzenesulfinic acid 
• 765-69-5 2-Methylcyclopentane-1,3-dione 
• 25112-78-1 2-methyl-2-(3-oxobutyl)-1,3-cyclopentanedione 
• 33879-04-8 (+)-(3aS,7aS)-2,3,3a,4,7,7a-hexahydro-3a-hydroxy-7a-methyl-1H-indene-1,5(6H)-dione 

Downstream Products

• 88248-04-8 (-)-17α-ethynyl-2-oxo-4-norestr-3(5)-en-17β-yl propionate 
• 64675-08-7 dinordrin 
• 119616-58-9 (S)-4-Benzenesulfonylmethyl-7a-methyl-hexahydro-indene-1,5-dione 
• 61530-86-7 (3aS,4S,7aS)-2,3,3a,6,7,7a-Hexahydro-7a-methyl-4-<(phenylsulfonyl)methyl>-1H-inden-1,5(4H)-dion 

Relevant academic research and scientific papers

Construction of key building blocks towards the synthesis of cortistatins

This work reports the construction of key building blocks towards the synthesis of cortistatins; a family of steroidal alkaloids. Cortistatin A, being a primary target due to its superior biological properties over other congeners, has been prepared by two different synthetic routes. Synthesis of the precursor to the heavily substituted A-ring starting from d-glucose and construction of the DE-ring junction employing a Hajos-Parrish ketone as a chiral pool have been demonstrated. Efforts are underway to assemble these key fragments and build towards the total synthesis of cortistatin A.

Total Synthesis of Dinordrin and Analogues

A total synthesis of optically active dinordrin (3c) is detailed, following a flexible and stereoselective route.A number of unexpected and potentially useful by-products have been identified.The preparation of the novel A-nor-steroid analogues (19), (20)

Process for the preparation of 13β-alkyl-4-gonene-3,17-diones

Novel process for the preparation of 13β-alkyl-4-gonene-3,17-diones of the formula STR1 wherein R1 is methyl or ethyl, consists of REACTING A 7Aβ-ALKYL,5,6,7,7A-TETRAHYDROINDANE-1,5-DIONE WITH FORMALDEHYDE AND AN ARYLSULFINIC ACID OR AN ADDUCT OF FORMALDEHYDE AND ARYLSULFINIC ACID TO PRODUCE A TETRAHYDROINDANE DERIVATIVE; Hydrogenating the tetrahydroindane derivative with hydrogen in the presence of a palladium-, platinum-, or rhodium-containing hydrogenation catalyst to produce a perhydroindane derivative; Condensing the perhydroindane derivative in the presence of a proton-accepting agent with a 7,7-alkylenedioxy-3-oxooctanoic acid ester; Treating the product obtained with a strong aqueous base and then heating the product in an inert solvent to produce a 4,5-secosteroid; Hydrogenating the 4,5-secosteroid in the presence of a palladium-, platinum-, rhodium-, or nickel-containing hydrogenation catalyst; and Hydrolyzing and cyclizing the hydrogenated 4,5-secosteroid by treatment with a strong acid.