61532-31-8Relevant academic research and scientific papers
Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents
Lukasik, Pawel M.,Elabar, Sherifa,Lam, Frankie,Shao, Hao,Liu, Xiangrui,Abbas, Abdullah Y.,Wang, Shudong
, p. 311 - 322 (2013/01/15)
A series of N-phenyl-imidazo[4,5-b]pyridin-2-amines, 4-indazolyl-N- phenylpyrimidin-2-amines and N-phenyl-4-pyrazolo[3,4-b]pyridin-pyrimidin-2- amines have been synthesized. Their anti-proliferative activities were tested in HCT-116 human colon carcinoma and MCF-7 breast carcinoma cell lines. Many exhibited potent anti-proliferative and CDK9 inhibitory activities. A lead compound 18b demonstrated the ability to reduce the level of Mcl-1 anti-apoptotic protein, to activate caspase 3/7 and induce cancer cell apoptosis.
THIONATION OF IMIDAZOPYRIDINES
Yutilov, Yu.M.,Svertilova, I.A.
, p. 653 - 658 (2007/10/02)
Direct thionation of imidazopyridines and imidazopyridines results in the formation of their 2-thioxo derivatives, usually in high yield.The thione structure of the imidazopyridines obtained has been confirmed from their IR spectra in the solid state and in solution.The general nature of the thionation of imidazole, benzimidazole, imidazopyridine, imidazopyridine, and purine has been noted as one of the distinctive chemical properties of compounds in this series of nitrogen heterocycles.
