61533-67-3

Basic information

• Product Name: 2-Benzoxazolemethanol, a-methyl-
• Synonyms: 1-Benzooxazol-2-yl-ethanol;1-(1,3-benzoxazol-2-yl)ethanol;2-Benzoxazolemethanol, α-methyl-;1-(1,3-Benzoxazol-2-yl)ethan-1-ol
• CAS NO: 61533-67-3
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17
• Mol File: 61533-67-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 29-31 °C
• Boiling Point: 260.8±23.0 °C(Predicted)
• Appearance: /
• Density: 1.249±0.06 g/cm3(Predicted)
• PKA: 13.34±0.20(Predicted)
• CAS DataBase Reference: 2-Benzoxazolemethanol, a-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzoxazolemethanol, a-methyl-(61533-67-3)
• EPA Substance Registry System: 2-Benzoxazolemethanol, a-methyl-(61533-67-3)

Safety Data

• Hazardous Substances Data: 61533-67-3(Hazardous Substances Data)

Upstream product

• 615-18-9 2-chloro-1,3-benzoxazole 
• 64-17-5 ethanol 
• 122433-29-8 1-(benzo[d]oxazol-2-yl)ethanone 
• 849585-22-4 LACTIC ACID 
• 95-55-6 2-amino-phenol 
• 124855-83-0 5a,6,11a,12-Tetrahydro-5a-methyl<1,4>benzoxazino<3,2-b><1,4>benzoxazine 

Downstream Products

• 1315309-31-9 (S)-1-(benzoxazol-2-yl)ethan-1-ol 
• 1315309-26-2 C₂₃H₁₉NO₃ 
• 124855-89-6 2-<1-(2-Benzoxazolyl)ethylidenamino>phenol 
• 122433-29-8 1-(benzo[d]oxazol-2-yl)ethanone 
• 1308372-81-7 C₁₈H₁₇NO₃ 
• 1308372-75-9 C₁₈H₁₇NO₃ 

Relevant articles and documents

Direct α-Arylation of Alcohols with Aryl Halides through a Radical Chain Mechanism

Alcohols were found to be arylated directly at their α-C?H bond with aryl halides in the presence of a base and a substoichiometric amount of t-BuOOt-Bu through a homolytic aromatic substitution mechanism. (Figure presented.).

Development of benzoxazole deoxybenzoin oxime and acyloxylamine derivatives targeting innate immune sensors and xanthine oxidase for treatment of gout

Both the inhibition of inflammatory flares and the treatment of hyperuricemia itself are included in the management of gout. Extending our efforts to development of gout therapy, two series of benzoxazole deoxybenzoin oxime derivatives as inhibitors of innate immune sensors and xanthine oxidase (XOD) were discovered in improving hyperuricemia and acute gouty arthritis. In vitro studies revealed that most compounds not only suppressed XOD activity, but blocked activations of NOD-like receptor (NLRP3) inflammasome and Toll-like receptor 4 (TLR4) signaling pathway. More importantly, (E)-1-(6-methoxybenzo[d]oxazol-2-yl)-2-(4-methoxyphenyl)ethanone oxime (5d) exhibited anti-hyperuricemic and anti-acute gouty arthritis activities through regulating XOD, NLRP3 and TLR4. Compound 5d may serve as a tool compound for further design of anti-gout drugs targeting both innate immune sensors and XOD.

Sunflow: Sunlight Drives Fast and Green Photochemical Flow Reactions in Simple Microcapillary Reactors – Application to Photoredox and H-Atom-Transfer Chemistry

“Sunflow“ – The combination of a microcapillary reactor in continuous flow mode with sunlight as the most sustainable energy source imaginable was applied to a range of photoredox and H-atom-transfer reactions making them both fast and green.