61538-85-0

Upstream product

• 34549-93-4 ethyl 3-ethyl-4,5-dimethylpyrrole-2-carboxylate 
• 100-51-6 benzyl alcohol 
• 128773-38-6 benzyl 3-ethyl-4-t-butoxycarbonyl-5-methyl-pyrrole-2-carboxylate 
• 4949-45-5 benzyl 2-methylacetoacetate 
• 128773-39-7 2-benzyloxycarbonyl-3-ethyl-5-methyl-pyrrole-4-carboxylic acid 

Downstream Products

• 56015-18-0 benzyl 5-acetoxymethyl-3-ethyl-4-methylpyrrole-2-carboxylate 
• 32928-22-6 benzyl 3-ethyl-5-formyl-4-methylpyrrole-2-carboxylate 
• 160114-49-8 dibenzyl 4,4'-diethyl-3,3'-dimethyl-2,2'-pyrromethane-5,5'-dicarboxylate 
• 145696-53-3 benzyl-5-t-butoxycarbonyl-3',4-dimethyl-3,4'-diethyl-dipyrrylmethane-5'-carboxylate 
• 124281-51-2 3,13-diethyl-1,2,7,8,12,17,18,19-octamethyl-10,23-dihydrobilin dihydrobromide 
• 97336-42-0 3-ethyl-4,5-dimethyl-pyrrole-2-carbaldehyde 
• 159152-49-5 2,5-Bis(5'-benzyloxycarbonyl-4'-ethyl-3'-methylpyrrol-2'-ylmethyl)pyrrole 

Relevant academic research and scientific papers

Porphyrins with exocyclic rings. Part 22: Synthesis of deoxophylloerythroetioporphyrin (DPEP), three ring homologues, and five related nonpolar bacteriopetroporphyrins using a western ring closure and an improved b-bilene methodology

Dipyrrolic intermediates incorporating five-membered carbocyclic rings are easily prepared from cyclopenta[b]pyrroles, and this unit represents the southern half of the DPEP-type geoporphyrins found in organic-rich sediments such as oil shales and petroleum. Related dipyrroles with six-, seven- or eight-membered carbocyclic rings were shown to give b-bilenes when reacted with dipyrrylmethane carbaldehydes under mildly acidic conditions. Following deprotection of the terminal ester groups, cyclization with TFA-CH(OMe)3 gave a series of ring homologues of deoxophylloerythroetioporphyrin (DPEP). The b-bilenes generated from the five-membered ring dipyrroles proved to be rather unstable and had to be used directly without purification. Cyclization gave DPEP contaminated with an etioporphyrin by-product, but these could be separated as the nickel(II) derivatives by flash chromatography. This approach gave superior yields of DPEP compared to previously reported methods. In addition, the methodology could be extended to the synthesis of related petroporphyrins, and a series of five molecular fossils derived from bacteriochlorophylls d were synthesized by this approach.

A new convergent method for porphyrin synthesis based on a '3 + 1' condensation

A new methodology based on the '3 + 1' acid-catalytic condensation of tripyrranes and pyrrole-2,5-dicarbaldehyde has been used, for the first time, for the synthesis of two types of porphyrins: vic-dipropionic ester porphyrins 30 and 31 including an analo

CONCERNING THE MECHANISM OF FORMATION OF BILIVERDINS FROM b-BILENES

The oxidation of 1,19-di-t-butoxycarbonyl-b-bilenes with bromine affords not only a major biliverdin, but also minor biliverdins.Elucidation of their structure revealed that cleavage of the b-bilene chain takes place during the oxidation, followed by dime