61538-99-6

Upstream product

• 17649-86-4 4,4-bis(methylthio)but-3-en-2-one 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 75-15-0 carbon disulfide 
• 5586-88-9 1-(4-chlorophenyl)propan-2-one 
• 74-88-4 methyl iodide 

Downstream Products

• 1426691-73-7 2,4-bis(4-chlorophenyl)-3-(methylthio)cyclopent-2-enone 
• 1426691-48-6 (E)-2,5-bis(4-chlorophenyl)-1,1-bis(methylthio)penta-1,4-dien-3-one 
• 1426691-72-6 2-(4-chlorophenyl)-3-(methylthio)-4-phenylcyclopent-2-enone 
• 1426691-47-5 (E)-2-(4-chlorophenyl)-1,1-bis(methylthio)-5-phenylpenta-1,4-dien-3-one 

Relevant academic research and scientific papers

Photoredox-Catalyzed C-H Arylation of Internal Alkenes to Tetrasubstituted Alkenes: Synthesis of Tamoxifen

Visible-light-induced direct C-H arylation of S,S-functionalized internal alkenes, that is, α-oxo ketene dithioacetals and analogues, has been efficiently realized with aryldiazonium salts (ArN2BF4) as coupling partners and Ru(bpy)s

Controlled Ring-Opening of Siloxydifluorocyclopropanes for Carbocyclization: Synthesis of Difluorocyclopentenones

A highly controlled ring opening of siloxydifluorocyclopropanes, formed by nBuN4Br-catalyzed difluorocyclopropanation of methyl vinyl ketones bearing a β-alkylthio group by using TMSCF2Br as a unique difluorocarbene source, results in metal difluorohomoenolates with assistance of copper or silver followed by an intramolecular addition and elimination reaction leading to α-gem-difluorocyclopentenones efficiently.

Pd-Catalyzed C-S Activation/Isocyanide Insertion/Hydrogenation Enables a Selective Aerobic Oxidation/Cyclization

Unique imidoylation of thioorganics with isocyanides endows an unprecedented aerobic oxidation process. Catalyzed by Pd(Ph3P)2Cl2 in the presence of Ph3SiH under N2 then upon exposure to air, a wide range of α-acyl ketene dithioacetals react with isocyanides to afford 5-hydroxy-α,β-unsaturated γ-lactams via a C-S bond activation, isocyanide migratory insertion, hydrogenation, selective aerobic oxidation, and intramolecular nucleophilic addition sequence.

Regio- and stereoselective synthesis of 2-cyclopentenones via a hydrogenolysis-terminated Heck cyclization of β-alkylthio dienones

Palladium-catalyzed cyclization of β-alkylthio dienone derivatives affords 2-cyclopentenones in a regio- and stereoselective manner in the presence of silane. C-S activation, intramolecular carbopalladation and hydrogenolysis construct the cascade process