61550-88-7Relevant articles and documents
A versatile route to potential dehydrofolate reductase inhibitors via the hitherto unknown 6-benzyl-2-(O-methyl)uracils: Synthesis of isotrimethoprim
Botta,Artico,Massa,Gambacorta
, p. 883 - 884 (1989)
The synthesis of 2,4-diamino-6-(3,4,5-trimethoxybenzyl)pyrimidine (isotrimethoprim) has been accomplished starting from 2-(O-methyl)-6-(3,4,5-trimethoxybenzyl)uracil by standard procedures. The benzyluracil derivative has been obtained by reacting O-methy