61550-88-7Relevant academic research and scientific papers
A versatile route to potential dehydrofolate reductase inhibitors via the hitherto unknown 6-benzyl-2-(O-methyl)uracils: Synthesis of isotrimethoprim
Botta,Artico,Massa,Gambacorta
, p. 883 - 884 (1989)
The synthesis of 2,4-diamino-6-(3,4,5-trimethoxybenzyl)pyrimidine (isotrimethoprim) has been accomplished starting from 2-(O-methyl)-6-(3,4,5-trimethoxybenzyl)uracil by standard procedures. The benzyluracil derivative has been obtained by reacting O-methy
Synthesis, antimicrobial and antiviral activities of isotrimethoprim and some related derivatives
Botta,Artico,Massa,Gambacorta,Marongiu,Pani,La Colla
, p. 251 - 257 (2007/10/02)
The synthesis and the antimicrobial activities of 2,4-diamino-6-(3,4,5-trimethoxybenzyl)pyrimidine (isotrimethoprim) and some related derivatives are reported. The new derivatives have been found scarcely active against bacteria and fungi, with the only e
