A versatile route to potential dehydrofolate reductase inhibitors via the hitherto unknown 6-benzyl-2-(O-methyl)uracils: Synthesis of isotrimethoprim

DOI: 10.1002/jhet.5570260372

Source and publish data:

Journal of Heterocyclic Chemistry p. 883 - 884 (1989)

Update date:2022-08-11

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Authors:

Botta Botta

Artico Artico

Massa Massa

Gambacorta

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Article abstract of DOI:10.1002/jhet.5570260372

The synthesis of 2,4-diamino-6-(3,4,5-trimethoxybenzyl)pyrimidine (isotrimethoprim) has been accomplished starting from 2-(O-methyl)-6-(3,4,5-trimethoxybenzyl)uracil by standard procedures. The benzyluracil derivative has been obtained by reacting O-methy

Full text of DOI:10.1002/jhet.5570260372

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