615556-57-5Relevant academic research and scientific papers
1-Toluene-sulfonyl-3-[(3′-hydroxy-5′-substituted)-γ-butyrolactone]-indoles: Synthesis, COX-2 inhibition and anti-cancer activities
Singh, Palwinder,Mittal, Anu,Bhardwaj, Atul,Kaur, Satwinderjeet,Kumar, Subodh
, p. 85 - 89 (2008/09/18)
Indoles carrying a cyclic ester (γ-butyrolactone) at C-3 position have been synthesized by the allylation of 3-indoleglyoxylate followed by iodocyclisation and the nucleophilic replacement of the iodo-group. Screening of these molecules for COX-2 inhibiti
