6156-88-3

Basic information

• Product Name: 5-propylpyrimidine-2,4,6(1H,3H,5H)-trione
• CAS NO: 6156-88-3
• Molecular Formula: C₇H₁₀N₂O₃
• Molecular Weight: 170.1659
• Mol File: 6156-88-3.mol
• Article Data: 3

Chemical Properties

• Density: 1.197g/cm³
• Refractive Index: 1.467
• CAS DataBase Reference: 5-propylpyrimidine-2,4,6(1H,3H,5H)-trione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-propylpyrimidine-2,4,6(1H,3H,5H)-trione(6156-88-3)
• EPA Substance Registry System: 5-propylpyrimidine-2,4,6(1H,3H,5H)-trione(6156-88-3)

Safety Data

• Hazardous Substances Data: 6156-88-3(Hazardous Substances Data)

Usage

General Description

5-propylpyrimidine-2,4,6(1H,3H,5H)-trione, also known as propylbarbituric acid, is a chemical compound with the molecular formula C9H12N2O3. It is a derivative of barbituric acid and belongs to the class of barbiturate drugs, which are commonly used as sedatives, hypnotics, and anesthetics. Propylbarbituric acid has similar properties to other barbiturates, such as its ability to depress the central nervous system, leading to sedative and hypnotic effects. It is used in the treatment of various medical conditions, including epilepsy, anxiety, and insomnia. However, it is important to note that barbiturates have a high potential for abuse and addiction, and their use should be closely monitored and regulated by healthcare professionals.

Upstream product

• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 860725-99-1 5-bromo-5-propyl-pyrimidine-2,4,6-trione 
• 2163-48-6 diethyl propylmalonate 
• 57-13-6 urea 

Downstream Products

• 58-81-1 2,4,6-trichloro-5-propyl-pyrimidine 
• 1310053-30-5 6-[4-(3-trifluoromethylphenyl)-1-piperazinyl]-5-(n-propyl)uracil 
• 1310053-29-2 6-[4-(2-methoxyphenyl)-1-piperazinyl]-5-(n-propyl)uracil 
• 1310053-28-1 6-(4-phenyl-1-piperazinyl)-5-(n-propyl)uracil 
• 112055-03-5 5-propyl-5-<(4-methylbenzoylamino)(4-pyridyl)methyl>barbituric acid 
• 112055-02-4 5-propyl-5-<(3,5-dimethylbenzoylamino)(4-pyridyl)methyl>barbituric acid 
• 112055-01-3 5-propyl-5-<(4-nitrobenzoylamino)(4-pyridyl)methyl>barbituric acid 
• 112055-06-8 5-propyl-5-<(4-methoxybenzoylamino)(4-pyridyl)methyl>barbituric acid 
• 112055-04-6 5-propyl-5-<(2-methylbenzoylamino)(4-pyridyl)methyl>barbituric acid 
• 7296-17-5 5-Allyl-5-propyl-barbitursaeure 
• 66984-60-9 5-benzyl-5-propyl-barbituric acid 

Relevant articles and documents

Synthesis and antimicrobial activity of some novel 5-alkyl-6-substituted uracils and related derivatives

6-Chloro-5-ethyl-, n-propyl- and isopropyluracils 5a-c were efficiently prepared from the corresponding 5-alkybarbituric acids 3a-c via treatment with phosphorus oxychloride and N,N-dimethylaniline to yield the corresponding 5-alkyl-2,4,6-trichloropyrimidines 4a-c, which were selectively hydrolyzed by heating in 10% aqueous sodium hydroxide for 30 minutes. The reaction of compounds 5a-c with 1-substituted piperazines yielded the corresponding 5-alkyl-6-(4-substituted-1-piperazinyl)uracils 6a-j. The target 8-alkyltetrazolo[1,5-f]pyrimidine-5,7(3H,6H)-diones 7a-c were prepared via the reaction of 5a-c with sodium azide. Compounds 6a-j and 7a-c were tested for in vitro activities against a panel of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Compound 6h displayed potent broad-spectrum antibacterial activity, while compound 6b showed moderate activity against the Gram-positive bacteria. All the tested compounds were practically inactive against Candida albicans.

Furans and pyrans. 5. Synthesis of furano-pyrimidines.

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