61565-75-1Relevant academic research and scientific papers
Dibenztroponeacetic and -propionic acids. Potent new antiinflammatory agents.
Dunn,J.P. et al.
, p. 1557 - 1562 (1977)
The syntheses and antiinflammatory assays of some dibenztroponeacetic and -propionic acids and derivatives are described. The most potent compound, d-2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)propionic acid, has a potency of ca, 70 times phenylbutazone in the rat carrageenan paw assay and two to three times indomethacin in long-term animal assays. Some beta-dialkylaminoethyl esters of this compound also show high antiinflammatory activity.
