Journal of Medicinal Chemistry p. 1557 - 1562 (1977)
Update date:2022-08-04
Topics:
Dunn,J.P. et al.
The syntheses and antiinflammatory assays of some dibenztroponeacetic and -propionic acids and derivatives are described. The most potent compound, d-2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)propionic acid, has a potency of ca, 70 times phenylbutazone in the rat carrageenan paw assay and two to three times indomethacin in long-term animal assays. Some beta-dialkylaminoethyl esters of this compound also show high antiinflammatory activity.
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Doi:10.1021/ja00443a056
(1977)Doi:10.1016/S0957-4166(98)00484-4
(1998)Doi:10.1002/hc.10180
(2003)Doi:10.1016/0040-4020(76)80093-2
(1976)Doi:10.1016/S0022-2860(03)00346-6
(2003)Doi:10.1021/jo00432a036
(1977)
