61594-81-8

Basic information

• Product Name: Benzaldehyde, 4-amino-2-methyl-
• CAS NO: 61594-81-8
• Molecular Formula: C8H9NO
• Molecular Weight: 135.166
• Mol File: 61594-81-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 4-amino-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-amino-2-methyl-(61594-81-8)
• EPA Substance Registry System: Benzaldehyde, 4-amino-2-methyl-(61594-81-8)

Safety Data

• Hazardous Substances Data: 61594-81-8(Hazardous Substances Data)

Upstream product

• 99-51-4 4-nitro-o-xylene 
• 68-12-2 N,N-dimethyl-formamide 
• 108-44-1 1-amino-3-methylbenzene 

Downstream Products

• 317374-08-6 2-methyl-4-(2-methylbenzoylamino)benzoic acid 
• 2486-75-1 4-amino-2-methylbenzoic acid 
• 838858-87-0 N-[4-(acetyloxymethyl)-2-cyano-5-methylphenyl]-acetamide 
• 838858-88-1 4-(acetylamino)-5-bromo-2-methylbenzyl acetate 
• 63405-88-9 4-amino-2-methyl-benzyl alcohol 
• 84257-47-6 4'-(2-aminopropyl)-3'-methylbenzenesulfonanilide 
• 84257-53-4 1-(4-amino-2-methylphenyl)-2-nitropropane 
• 84257-46-5 3'-methyl-4'-(2-nitropropen-1-yl)benzenesulfonanilide 
• 84257-52-3 3-methyl-4-(2-nitropropyl)acetanilide 
• 84257-51-2 3-methyl-4-(2-nitropropen-1-yl)acetanilide 
• 84257-45-4 4'-formyl-3'-methylbenzenesulfonanilide 
• 84257-50-1 4-acetamido-2-methyl benzaldehyde 

Relevant articles and documents

Chemical development of ZD9331: Synthesis of a bromomethylquinazolinone avoiding a nonselective radical bromination

An efficient regiospecific synthesis of ZD9331 Pivaloyloxymethyl (POM) Bromide (4) has been accomplished via ZD9331 Quinacetate HCl (15) avoiding a nonselective bromination. The original route used a radical bromination on a substrate with three methyl groups, which generated a range of bromomethyl derived compounds that carried through to the final active pharmaceutical ingredient (API). A strategy, based on the Zinin reaction, was developed to synthesize the required bromomethyl compound in a regioselective manner. This approach was successfully scaled to manufacture a tonne of material.

N-desmethyl analogues of (+)-4-dimethylamino-2,α-dimethylphenethylamine. Synthesis and configurational relationships

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