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5-Methylhydantoin is a heterocyclic compound derived from Hydantoin, which is used as a key intermediate in the synthesis of various pharmaceutical products, particularly anticonvulsants such as fosphenytoin.

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  • 616-03-5 Structure
  • Basic information

    1. Product Name: 5-Methylhydantoin
    2. Synonyms: 5-Methyl-2,4-imidazolidinedione;Hydantoin, 5-methyl-;DL-5-METHYLHYDANTOIN;5-METHYLIMIDAZOLIDINE-2,4-DIONE;5-METHYLHYDANTOIN;5-Methylhydantoin,98%;(S)-5-Methylhydantoin;5-METHYLHYDANTION
    3. CAS NO:616-03-5
    4. Molecular Formula: C4H6N2O2
    5. Molecular Weight: 114.1
    6. EINECS: N/A
    7. Product Categories: Hydantoins and Derivatives;Hydantoins & Derivatives;Building Blocks;Heterocyclic Building Blocks;Imidazolines/Imidazolidines
    8. Mol File: 616-03-5.mol
  • Chemical Properties

    1. Melting Point: 148-152 °C(lit.)
    2. Boiling Point: 213.59°C (rough estimate)
    3. Flash Point: N/A
    4. Appearance: white to off-white crystalline powder
    5. Density: 1.3565 (rough estimate)
    6. Refractive Index: 1.4487 (estimate)
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: Methanol (Slightly), Water (Slightly)
    9. PKA: 8.91±0.10(Predicted)
    10. Water Solubility: Insoluble in water.
    11. BRN: 81081
    12. CAS DataBase Reference: 5-Methylhydantoin(CAS DataBase Reference)
    13. NIST Chemistry Reference: 5-Methylhydantoin(616-03-5)
    14. EPA Substance Registry System: 5-Methylhydantoin(616-03-5)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26-36
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 616-03-5(Hazardous Substances Data)

616-03-5 Usage

Uses

Used in Pharmaceutical Industry:
5-Methylhydantoin is used as a reactant for the preparation of N-chlorohydantoin, which is an important intermediate in the synthesis of various pharmaceutical compounds.
Used in Organic Chemistry:
5-Methylhydantoin is used as a reactant in the Mitsunobu reaction, a widely used method for the inversion of stereochemistry at a carbon center, facilitating the synthesis of enantiomerically pure compounds.
Used in Biochemical Processes:
5-Methylhydantoin is used in the conversion process by Pseudomonas putida strain, which allows the conversion of D-5-methylhydantoin into L-amino acids, an essential step in the production of certain pharmaceuticals and biologically active compounds.
Used in Enzymatic Reactions:
5-Methylhydantoin is used in enzymatic racemization, where D-hydantoinase from Agrobacterium tumefaciens catalyzes the conversion of D-5-methylhydantoin to its L-form, enabling the production of enantiomerically pure compounds for various applications.

Check Digit Verification of cas no

The CAS Registry Mumber 616-03-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,1 and 6 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 616-03:
(5*6)+(4*1)+(3*6)+(2*0)+(1*3)=55
55 % 10 = 5
So 616-03-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H6N2O2/c1-2-3(7)6-4(8)5-2/h2H,1H3,(H2,5,6,7,8)/t2-/m0/s1

616-03-5 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (L11992)  5-Methylhydantoin, 98%   

  • 616-03-5

  • 1g

  • 456.0CNY

  • Detail
  • Alfa Aesar

  • (L11992)  5-Methylhydantoin, 98%   

  • 616-03-5

  • 5g

  • 1520.0CNY

  • Detail
  • Aldrich

  • (533653)  5-Methylhydantoin  97%

  • 616-03-5

  • 533653-1G

  • 374.40CNY

  • Detail

616-03-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Methylhydantoin

1.2 Other means of identification

Product number -
Other names 5-methylimidazolidine-2,4-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:616-03-5 SDS

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