61607-66-7

Usage

Uses

Used in Pharmaceutical Industry:
(6R-trans)-7-amino-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is used as an impurity in the production of Cefotiam Dihydrochloride, a cephalosporin antibiotic. Its presence in the manufacturing process may affect the purity and efficacy of the final product. Therefore, it is important to monitor and control the levels of this impurity to ensure the quality and safety of the antibiotic.

InChI:InChI=1/C13H19N7O3S2/c1-18(2)3-4-19-13(15-16-17-19)25-6-7-5-24-11-8(14)10(21)20(11)9(7)12(22)23/h8,11H,3-6,14H2,1-2H3,(H,22,23)/t8-,11-/m1/s1

Upstream product

• 61607-68-9 1-[2-(dimethylamino)ethyl]-1,2-dihydro-5H-tetrazole-5-thione 
• 61607-11-2 (6R)-3-acetoacetyloxymethyl-7t-((R)-5-carboxy-5-phthalimido-pentanoylamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 957-68-6 7-Aminocephalosporanic acid 
• 61607-10-1 (6R)-7t-((R)-5-carboxy-5-phthalimido-pentanoylamino)-3-hydroxymethyl-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; bis-triethylamine salt 

Downstream Products

• 80789-89-5 C₂₅H₂₈N₈O₃S₂ 

Relevant academic research and scientific papers

A synthesis method of cefotiam hydrochloride (by machine translation)

The invention belongs to the field of medical technology, discloses a method for synthesis of cefotiam hydrochloride. In order to 7 - aminocephalosporanic acid and 1 - (2 - dimethyl amino ethyl) - 1 H - 5 - mercapto - tetrazole as raw materials, high concentration boron trifluoride dimethyl carbonate complex as a catalyst, in the mixed solvent in the condensation reaction to obtain the three intermediate, with the amino thiazole acetyl chloride reaction to obtain the cefotiam hydrochloride. The present invention provides a method for the stable and smooth reaction, few by-products, the production of cefotiam hydrochloride yield and purity is ideal. (by machine translation)

Preparation method for cefotiam hydrochloride

The invention provides a preparation method for cefotiam hydrochloride. The preparation method is characterized by comprising the following steps; adopting boron trifluoride complex to catalyze condensation reaction of 7-aminocephalosporanic acid and 1-(2-dimethyl aminoethyl)-1H-5-tetrazole-thione in case of taking dimethyl carbonate as a solvent; without crystallizing and separating, taking purewater as a reaction solvent and performing condensation on the pure water and aminothiazole acetyl chloride hydrochloride to form cefotiam; and performing hydrochloric acid acidification and crystallization on cefotiam to obtain cefotiam hydrochloride. A solvent used in the preparation method can be recycled, so that environment-friendly pressure is greatly reduced, environmental pollution is small, and indexes of cefotiam hydrochloride are improved while cost is reduced.

A kind of cefotiam hydrochloride preparation method (by machine translation)

The invention discloses a method for preparing cefotiam hydrochloride. The method comprises the following steps: carrying out a condensation reaction by using 7-ACA and DMMT as raw materials, a boron trifluoride acetonitrile complex as a catalyst and acetonitrile as a reaction solvent to prepare a 7-ACMT reaction liquid; carrying out a 'one-pot' acylation on the reaction liquid with ATC.HCl after treatment of direct water addition and alkali regulation without separating and purifying 7-ACMT; extracting and separating organic impurities from the acylation reaction liquid by acidification and organic solvent, and adding hydrophilic solvent to separate high-purity cefotiam hydrochloride. According to the method, two reactions are carried out in one step, the equipment using efficiency and labor efficiency can be improved, the labor intensity is reduced, the product yield is improved on the premise of guaranteeing the product quality, and the production cost is reduced; all impurity separating operations are carried out after the acylation reaction, product loss caused by intermediate separating operation can be reduced, and the product purity can be guaranteed.