61607-68-9

Basic information

• Product Name: 1-[2-(Dimethylamino)ethyl]-1H-tetrazole-5-thiol
• Synonyms: 1-N,N-DIMETHYLAMINOETHYL-5-MERCAPTO-1H-TETRAZOLE;1-(2-DIMETHYLAMINOETHYL)-1H-TETRAZOLE-5-THIOL;1-(2-DIMETHYLAMINOETHYL)-5-MERCAPTO-1,2,3,4-TETRAZOLE;1-(2-DIMETHYLAMINOETHYL)-5-MERCAPTOTETRAZOLE;1,2'-DIMETHYLAMINO-ETHYL-5-MERCAPTO-TETRAZOLE;1-[2-(dimethylamino)ethyl]-1,2-dihydro-5h-tetrazole-5-thione;MTZ;2-Dimethylaminoethyl)-5-Mercaptotetrazole
• CAS NO: 61607-68-9
• Molecular Formula: C₅H₁₁N₅S
• Molecular Weight: 173.24
• EINECS: 262-868-9
• Product Categories: Tetrazoles;Building Blocks;Heterocyclic Building Blocks
• Mol File: 61607-68-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 215 °C (dec.)(lit.)
• Boiling Point: 202.6 °C at 760 mmHg
• Flash Point: 76.3 °C
• Appearance: /
• Density: 1.36 g/cm³
• Vapor Pressure: 0.289mmHg at 25°C
• Refractive Index: 1.662
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Methanol (Slightly), Water (Sparingly, Heated)
• PKA: 8.06±0.20(Predicted)
• CAS DataBase Reference: 1-[2-(Dimethylamino)ethyl]-1H-tetrazole-5-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(Dimethylamino)ethyl]-1H-tetrazole-5-thiol(61607-68-9)
• EPA Substance Registry System: 1-[2-(Dimethylamino)ethyl]-1H-tetrazole-5-thiol(61607-68-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 1325
• WGK Germany: 3
• HazardClass: 4.1
• PackingGroup: III
• Hazardous Substances Data: 61607-68-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 61607-68-9 differently. You can refer to the following data:
1. 1-(2-Dimethylaminoethyl)-5-mercaptotetrazole is an impurity of Cefotiam, a semi-synthetic cephalosporin antibiotic.
2. 1-(2-Dimethylaminoethyl)-5-mercaptotetrazole is an impurity of?Cefotiam, a?semi-synthetic cephalosporin antibiotic.

InChI:InChI=1/C5H11N5S/c1-9(2)3-4-10-5(11)6-7-8-10/h3-4H2,1-2H3,(H,6,8,11)

Upstream product

• 7097-89-4 2-dimethylaminoethyl isothiocyanate 
• 4648-54-8 trimethylsilylazide 
• 66309-55-5 [2-(dimethylamino)ethyl]carbamodithioic acid methyl ester 

Downstream Products

• 61607-66-7 (6R,7R)-7-amino-3-[((1-(2-(methylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl]-8-oxo-5-thia-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 141463-27-6 {(1S,2R)-1-Cyclohexylmethyl-3-[1-(2-dimethylamino-ethyl)-1H-tetrazol-5-ylsulfanyl]-2-hydroxy-propyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Synthesis method of 1-(2-dimethylaminoethyl)-1H-5-sulfydryl-tetrazole

The invention relates to a synthesis method of 1-(2-dimethylaminoethyl)-1H-5-sulfydryl-tetrazole. The synthesis method comprises the following steps: (1) with sodium N, N-dimethyl ethylenediamine dithiocarboxylate and sodium azide as raw materials, water as a reaction solvent and an alkaline solution as a catalyst, carrying out heating reflux, and after the reaction is finished, neutralizing the reaction solution with an acid to obtain a crude 1-(2-dimethylaminoethyl)-1H-5-sulfydryl-tetrazoleproduct; and (2) recrystallizing the crude 1-(2-dimethylaminoethyl)-1H-5-sulfydryl-tetrazole product obtained in step (1) through a recrystallization solution to obtain the 1-(2-dimethylaminoethyl)-1H-5-sulfydryl-tetrazole finished product, wherein the recrystallization solution is a mixed solution ofmethylbenzene and water. The product prepared by the method has the advantages of high purity and high yield, the reaction process is safe, and the method is a green and environment-friendly synthesisprocess.

NOVEL QUINOXALINE DERIVATIVES

This invention relates to a novel compound represented by the following Chemical Formula 1, a process for preparing it, and its pharmaceutically approved salt comprising it as an active ingredient. The compound of this invention is GLP 1 receptor regulating low molecular weight compound useful for treatment of metabolic diseases such as diabetes and obesity by regulating the function of glucagon like peptide 1 receptor (GLP 1 receptor) for the disease or disorder carried by GLP 1 since it has the effects on a drop of blood sugar and an improvement of insulin resistance

Cephalosporin derivatives and bactericides containing the same

Cephalosporin compounds represented by the following formula (I) and pharmaceutically acceptable salts thereof have a broad bactericidal spectrum against various pathogenic bacteria including Psuedomonas aeruginosa and are useful as bactericidal remedies for pathogenic diseases of human and animals: STR1 wherein A represents an unsubstituted or substituted pyridylthio group of a formula (I-1); STR2 or an unsubstituted or substituted pyridiniumthio group of a formula (I-2): STR3 or an unsubstituted or substituted pyridinium group of a formula (I-3); STR4 or a 5- or 6-membered heterocyclicthio or bicycloheterocyclicthio group of a formula (I-4):