616207-84-2

Upstream product

• 616207-87-5 Acrylic acid (Z)-(1R,4S)-1-allyl-4-benzyloxymethyl-2-methyl-hex-2-enyl ester 
• 616207-89-7 (4S,6R)-6-((Z)-(S)-3-Benzyloxymethyl-1-methyl-pent-1-enyl)-4-hydroxy-tetrahydro-pyran-2-one 
• 616207-88-6 (R)-6-((Z)-(S)-3-Benzyloxymethyl-1-methyl-pent-1-enyl)-5,6-dihydro-pyran-2-one 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 616207-90-0 (4S,6R)-6-((Z)-(S)-3-Benzyloxymethyl-1-methyl-pent-1-enyl)-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-pyran-2-one 

Downstream Products

• 616207-91-1 (Z)-(3S,5R,8S)-8-Benzyloxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-5-(2-methoxy-ethoxymethoxy)-6-methyl-dec-6-enoic acid methoxy-methyl-amide 

Relevant academic research and scientific papers

Synthetic studies of microtubule stabilizing agent peloruside A: An asymmetric synthesis of C10-C24 segment

An asymmetric synthesis of the C10-C24 fragment of the potent antitumor macrolide, peloruside A is described. All three stereogenic centers have been enantioselectively constructed utilizing Evans alkylation, Brown asymmetric allylboration, and a substrate controlled epoxide formation. Other key reactions involved Grubbs's ring-closing olefin metathesis and Ando's Z-selective olefination reaction.