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Usage

Uses

Used in Coordination Chemistry:
6,6'-difluoro-2,2'-bipyridine is utilized as a ligand for the synthesis of coordination complexes and metal-organic frameworks. Its unique structure allows it to chelate metal ions, creating stable complexes that are of interest in materials science and catalysis.
Used in Catalysis:
In the field of catalysis, 6,6'-difluoro-2,2'-bipyridine is employed to facilitate various chemical reactions. Its ability to coordinate with metal ions enhances the catalytic activity of metal centers, making it a valuable component in the development of new catalysts for industrial and academic applications.
Used in Materials Science:
6,6'-difluoro-2,2'-bipyridine contributes to the advancement of materials science by participating in the construction of metal-organic frameworks. These frameworks have potential applications in gas storage, separation processes, and as platforms for sensing and drug delivery systems due to their high porosity and tunable properties.
Used in Drug Discovery:
6,6'-difluoro-2,2'-bipyridine is also being studied for its potential applications in drug discovery. Its interaction with metal ions could lead to the development of new pharmaceutical agents, particularly those that require metal-based catalysts or chelating agents for their synthesis or mode of action.

Upstream product

• 144100-07-2 2-bromo-6-fluoropyridine 

Relevant academic research and scientific papers

Use of a fluorinated probe to quantitatively monitor amino acid binding preferences of ruthenium(ii) arene complexes

In order to address outstanding questions about ruthenium complexes in complex biological solutions, 19F NMR spectroscopy was used to follow the binding preferences between fluorinated RuII(η6-arene)(bipyridine) complexes and protected amino acids and glutathione. Reporting what ruthenium compounds bind to in complex environments has so far been restricted to relatively qualitative methods, such as mass spectrometry and X-ray spectroscopic methods; however, quantitative information on the species present in the solution phase cannot be inferred from these techniques. Furthermore, using 1H NMR, in water, to distinguish and monitor a number of different complex RuII(η6-arene) adducts forming is challenging. Incorporating an NMR active heteroatom into ruthenium organometallic complexes provides a quantitative, diagnostic 'fingerprint' to track solution-phase behaviour and allow for unambiguous assignment of any given adduct. The resulting 19F NMR spectra show for the first time the varied, dynamic behaviour of organoruthenium compounds when exposed to simple biomolecules in complex mixtures. The rates of formation of the different observed species are dramatically influenced by the electronic properties at the metal, even in a closely related series of complexes in which only the electron-donating properties of the arene ligand are altered. Preference for cysteine binding is absolute: the first quantitative solution-phase evidence of such behaviour.

Base-mediated syntheses of new 6,6′-di(polyfluoroalkoxy)-2,2′-bipyridines with 100% regioselectivity

Reactions of N,N-difluoro-2,2′-bipyridinium bis(tetrafluoroborate) (MEC-31) (1) with fluorinated alcohols RfOH [Rf = CF3CH2, CH2FCH2, CF3CF2CH2, CHF2CF2CH2, (CF3)2CH] 2a-e, in the presence of a base at 70°C without solvent, gave good yields of 6,6′-di(polyfluoroalkoxy)-2,2′-bipyridines 3a-e with 100% regioselectivity. Triethylamine with 1, produced 6,6′-difluoro-2,2-bipyridine (4).