616238-89-2Relevant academic research and scientific papers
Discovery and optimization of p38 inhibitors via computer-assisted drug design
Goldberg, Daniel R.,Hao, Ming-Hong,Qian, Kevin C.,Swinamer, Alan D.,Gao, Donghong A.,Xiong, Zhaoming,Sarko, Chris,Berry, Angela,Lord, John,Magolda, Ronald L.,Fadra, Tazmeen,Kroe, Rachel R.,Kukulka, Alison,Madwed, Jeffrey B.,Martin, Leslie,Pargellis, Christopher,Skow, Donna,Song, Jinhua J.,Tan, Zhulin,Torcellini, Carol A.,Zimmitti, Clare S.,Yee, Nathan K.,Moss, Neil
, p. 4016 - 4026 (2008/02/12)
Integration of computational methods, X-ray crystallography, and structure-activity relationships will be disclosed, which lead to a new class of p38 inhibitors that bind to p38 MAP kinase in a Phe out conformation.
Compounds useful in treating cytokine mediated diseases
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Page 32, (2008/06/13)
Disclosed are amide compounds of formula(I): wherein Ar1, Q, Y and R3-R6 of formula(I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating d
