404010-35-1Relevant articles and documents
Novel chromene diarylurea compounds, and preparation method and application thereof
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, (2017/08/28)
The invention relates to compounds represented by the general formula I, or isomers, pharmaceutical salts and solvates thereof; the invention also relates to a composition containing the compounds represented by the general formula I, or the isomers, the
KINASE INHIBITORS
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, (2014/10/16)
There are provided compounds of formula I, wherein R1A to R1E, R2 to R5, L and X1 to X3 have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
7-(Piperazine-1-Ymethyl)-1H-Indole-2-Carboxylic Acid (Phenyl)-Amide Derivatives and Allied Compounds as P38 Map Kinase Inhibitors for the Treatment of Respiratory Diseases
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Page/Page column 51, (2011/11/12)
The present invention provides compounds according to general formula (I) which are proposed for the treatment of respiratory complaints, particularly asthma and COPD.