61630-49-7

Basic information

• Product Name: (2Z,4Z,6Z,8Z)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraen-1-ol
• CAS NO: 61630-49-7
• Molecular Formula: C₂₁H₂₈O₂
• Molecular Weight: 312.4458
• Mol File: 61630-49-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 484.5°C at 760 mmHg
• Flash Point: 212.8°C
• Density: 0.997g/cm³
• Vapor Pressure: 3.36E-10mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: (2Z,4Z,6Z,8Z)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraen-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2Z,4Z,6Z,8Z)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraen-1-ol(61630-49-7)
• EPA Substance Registry System: (2Z,4Z,6Z,8Z)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraen-1-ol(61630-49-7)

Safety Data

• Hazardous Substances Data: 61630-49-7(Hazardous Substances Data)

Upstream product

• 74479-45-1 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid methyl ester 
• 62924-31-6 1-(2,5,6-trimethyl-4-methoxyphenyl)-but-1-en-3-one 
• 54344-92-2 2,3,6-trimethyl-4-methoxy-benzaldehyde 
• 20469-61-8 2,3,5-trimethylanisole 
• 41891-54-7 diethyl 3-(ethoxycarbonyl)-3-methylprop-2-en-yl phosphate 
• 51318-62-8 ethyl (E)-4-bromo-3-methyl-2-butenoate 
• 65527-85-7 ethyl (E)-4-hydroxy-3-methyl-2-butenoate 
• 697-82-5 2,3,5-trimethylphenol 
• 54350-48-0 etretinate 
• 63650-98-6 5-(4-methoxy-2,3,6-trimethylphenyl)-3-methylpenta-2,4-dien-1-ol 
• 1269259-99-5 (2E,4E)-ethyl 5-(-4-methoxy-2,3,6-trimethylphenyl)-3-methylpenta-2,4-dienoate 
• 67-56-1 methanol 
• 127613-71-2 9-(4-methoxy-2,3,6-trimethylphenyl)-4-carboxy-3,7-dimethyl-2Z,4Z,6E,8E-nonatetraenoic acid 
• 69427-46-9 13-cis-Acitretin 

Downstream Products

• 1621284-01-2 4,4’-((1E,3E,5E,7E,9E,11E,13E)-3,7,12-trimethyltetradeca-1,3,5,7,9,11,13-heptaene-1,14-diyl)bis(1-methoxy-2,3,5-trimethylbenzene) 
• 1621283-97-3 4,4’-((1E,3E,5E,7E,9E,11E,13E)-3,7,12-trimethyltetradeca-1,3,5,7,9,11,13-heptaene-1,14-diyl)bis(1-methoxy-2,3,5-trimethylphenol) 
• 69051-41-8 Methyl Ether of 9-(4-Methoxy-2,3,6-Trimethylphenyl)-3,7-Dimethyl-2,4,6,8-nonatetraene-1-ol 
• 58508-38-6 (2E,4E,6E,8E)-9-(4-methoxyl-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenal 

Relevant articles and documents

Tailoring 3,3'-dihydroxyisorenieratene to hydroxystilbene: Finding a resveratrol analogue with increased antiproliferation activity and cell selectivity

Four novel compounds were designed by "tailoring" 3,3'-dihydroxyisorenieratene (a natural carotenoid) based on an isoprene unit retention truncation strategy. Among them, the smallest molecule 1 (2,3,6,2',3',6'-hexamethyl-4,4'-dihydroxy-trans-stilbene) was concisely synthesized in a one-pot Stille-Heck tandem sequence, and surfaced as a promising lead molecule in terms of its selective antiproliferative activity mediated by blocking the NCI-H460 cell cycle in G1 phase. Additionally, theoretical calculations and cell uptake experiments indicate that the unique polymethylation pattern of compound 1 significantly induces a conformational change shift out of planarity and increases its cell uptake and metabolic stability. The observation should be helpful to rationally design resveratrol-inspired antiproliferative agents. Four novel compounds were designed by "tailoring" 3,3'-dihydroxyisorenieratene (a natural carotenoid) based on an isoprene unit retention truncation strategy. Among them, the smallest molecule 1 was concisely synthesized by a one-pot Stille-Heck tandem sequence, and surfaced as a promising lead molecule in terms of its selective antiproliferative activity (see figure).

9-Phenyl-nonate traene compounds

Novel 9-phenyl 5,6-dimethyl-nona-2,4,6,8-tetraenoic acid, tetraenal or tetraenol derivatives useful as anti-tumor agents.