61638-00-4

Upstream product

• 2684-02-8 benzenediazonium 
• 620-17-7 3-ethylphenol 
• 14143-34-1 3-ethyl-4-nitrophenol 
• 522613-61-2 (2-bromo-4-methoxy-phenyl)-carbamic acid tert-butyl ester 
• 32338-02-6 2-bromo-4-methoxyaniline 
• 62-53-3 aniline 
• 625119-87-1 (5-benzyloxy-2-nitrophenyl)ethene 
• 98491-59-9 3-ethyl-4-nitroso-phenol 

Downstream Products

• 1449669-33-3 [3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenoxy]acetonitrile 
• 1449665-25-1 2-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenoxy)acetonitrile 
• 1449669-32-2 3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenol 
• 14143-35-2 3-ethyl-4-dimethylamino-phenol 
• 99499-00-0 acetic acid-(2-ethyl-4-hydroxy-anilide) 

Relevant academic research and scientific papers

Traf2- AND Nck-INTERACTING KINASE (TNIK) INHIBITORS AND USES THEREOF

Compounds represented by Formula (I): wherein W is a nitrogen-containing moiety attached to said X via said nitrogen atom, and all other variables are as defined in the specification, processes of preparing same and uses thereof for treating medical conditions associated with upregulated activity of TNIK are provided.

COMPOUNDS FOR INHIBITING TNIK AND MEDICAL USES THEREOF

The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.

IMIDAZO [4, 5 -C] PYRIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES

Wherein R1, L1, R3, R4, Cy, L2 and R5 are as defined herein. Novel imidazolopyridines according to Formula I, able to inhibit JAK are disclosed, these compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic or inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons.

Positive allosteric modulators of the nicotinic acetylcholine receptor

The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which α7 nAChR is known to be involved.

Composition for the oxidation dyeing of keratinous fibres comprising a para-phenylenediamine, a meta-phenylenediamine and a para-aminophenol or a meta-aminophenol, and dyeing process

An oxidation dyeing composition for keratinous fibres, in particular human keratinous fibres such as hair, of the type comprising a medium suitable for dyeing, the medium containing at least one first para-phenylenediamine oxidation dye precursor containing a primary, secondary or tertiary amine function; at least one first meta-phenylenediamine coupling agent; and either at least one second para-aminophenol oxidation dye precursor or at least one second meta-aminophenol coupling agent; or the acid addition salts thereof. The use of this composition for dyeing keratinous fibres, in particular human keratinous fibres such as hair.

Hair dye compositions containing 3-substituted-4-aminophenols and 2-substituted-1-naphthols

A 2-Substituted-1-naphthol of the formula: STR1 wherein R1 is C1 -C6 alkyl or monohydroxy C1 -C6 alkyl couples with a primary intermediate of the formula: STR2 wherein R is C1 -C6 alkyl or monohydroxy C1 -C6 alkyl to produce an oxidative dye.

3-substituted para-aminophenols

The invention concerns the use of a 3-substituted para-aminophenol as an oxidation dye precursor for dyeing keratinous fibres, in particular human hair. The 3-substituted para-aminophenol has formula: STR1 where R1 represents alkyl, alkenyl, mono- or polyhydroxyalkyl, nitrile, cyanoalkyl, halogenoalkyl, aminoalkyl or alkoxyalkyl and R2 represents hydrogen, alkyl or mono- or polyhydroxyalkyl, provided that when R2 is hydrogen R1 is not methyl or trifluoromethyl, and to addition salts thereof with an acid. The invention also concerns dye compositions containing compound (I). The invention further concerns novel 3-substituted para-aminophenols.