61638-81-1

Basic information

• Product Name: Cyclohexane, (2-chloroethylidene)-
• CAS NO: 61638-81-1
• Molecular Formula: C8H13Cl
• Molecular Weight: 144.644
• Mol File: 61638-81-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Cyclohexane, (2-chloroethylidene)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexane, (2-chloroethylidene)-(61638-81-1)
• EPA Substance Registry System: Cyclohexane, (2-chloroethylidene)-(61638-81-1)

Safety Data

• Hazardous Substances Data: 61638-81-1(Hazardous Substances Data)

Upstream product

• 1940-19-8 1-vinylcyclohexanol 
• 75-36-5 acetyl chloride 
• 1552-92-7 ethyl cyclohexylideneacetate 
• 108-94-1 cyclohexanone 
• 932-89-8 2-cyclohexylidene ethanol 

Downstream Products

• 1443054-71-4 (3R,4R)-3-cyclohexenyl-1-tosylpiperidine-4-carbaldehyde 
• 1443054-37-2 N-(2-cyclohexylideneethyl)-4-methyl-N-(4-oxobutyl)benzenesulfonamide 
• 1607854-62-5 (R)-(1-(1-vinylcyclohexyl)allyl)benzene 
• 1607854-61-4 4,4,5,5-tetramethyl-2-(1-vinylcyclohexyl)-1,3,2-dioxaborolane 
• 66165-04-6 (2-cyclohexylideneethyl)(phenyl)sulfane 
• 1076239-09-2 (E)-methyl 4-cyclohexylidene-2-phenylbut-2-enoate 
• 66869-17-8 2-vinylcyclohexanecarbaldehyde 
• 84943-83-9 (1R,3aS,7aR)-4-[2-Cyclohexylidene-eth-(E)-ylidene]-1-(1,5-dimethyl-hexyl)-7a-methyl-octahydro-indene 
• 13303-59-8 (2-cyclohexylideneethyl)diphenylphosphine oxide 
• 52743-09-6 (2-Cyclohexylidene-ethyl)-(3-ethoxy-2-methyl-3,3-diphenyl-propyl)-amine 
• 52743-39-2 (3-Butoxy-3,3-diphenyl-propyl)-(2-cyclohexylidene-ethyl)-amine 

Relevant articles and documents

Synthesis method of 2-(1-cyclohexenyl) ethylamine

The invention belongs to the technical field of organic chemistry, and particularly relates to a synthesis method of a compound 2-(1-cyclohexenyl) ethylamine (I). Cyclohexanone (II) and a Grignard reagent are subjected to a Grignard reaction in an organic solvent to be converted into 1-vinyl cyclohexanol (III), the 1-vinyl cyclohexanol (III) and a chlorination reagent are subjected to a chlorination/rearrangement one-pot reaction in an organic solvent in the presence of organic alkali to prepare (2-chloroethylene methylene) cyclohexane (IV), the (2-chloroethylene methylene) cyclohexane (IV) and urotropine are subjected to quaternization in an organic solvent to form N-cyclohexylidene ethyl urotropine hydrochloride (V), and finally, hydrolysis rearrangement is carried out in a solvent in the presence of inorganic mineral acid to obtain the 2-(1-cyclohexenyl) ethylamine (I). The compound (I) has important industrial application value as an intermediate for synthesizing the antitussive drug dextromethorphan hydrobromide. The method has the advantages of cheap and accessible raw materials, mild reaction conditions, high yield and high product purity, is simple to operate, and is convenient for industrial production.

Enantioselective intramolecular aldehyde α-alkylation with simple olefins: Direct access to homo-ene products

A highly selective method for the synthesis of asymmetrically substituted carbocycles and heterocycles from unactivated aldehyde-olefin precursors has been achieved via enantioselective SOMO-catalysis. Addition of a catalytically generated enamine radical cation across a pendent olefin serves to establish a general asymmetric strategy toward the production of a wide range of formyl-substituted rings with alkene transposition. Conceptually, this novel mechanism allows direct access to "homo-ene"-type products.