61655-58-1

Basic information

• Product Name: 2-chloro-6-(1-piperazinyl)pyrazine monohydrochloride
• Synonyms: 2-chloro-6-(1-piperazinyl)pyrazine monohydrochloride;2-Chloro-6-(1-piperazinyl)-pyrazine hydrochloride;NSC 31732;2-chloro-6-(piperazin-1-yl)pyrazine hydrochloride
• CAS NO: 61655-58-1
• Molecular Formula: C8H12Cl2N4
• Molecular Weight: 235.11368
• EINECS: 262-883-0
• Mol File: 61655-58-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 364.1°C at 760 mmHg
• Flash Point: 174°C
• Appearance: white to off-white/
• Vapor Pressure: 1.73E-05mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: DMSO: ≥20mg/mL
• CAS DataBase Reference: 2-chloro-6-(1-piperazinyl)pyrazine monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-6-(1-piperazinyl)pyrazine monohydrochloride(61655-58-1)
• EPA Substance Registry System: 2-chloro-6-(1-piperazinyl)pyrazine monohydrochloride(61655-58-1)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 61655-58-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H11ClN4.ClH/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13;/h5-6,10H,1-4H2;1H

Upstream product

• 426829-52-9 tert-Butyl 4-(6-Chloro-2-Pyrazinyl)-1-Piperazinecarboxylate 
• 110-85-0 piperazine 
• 4774-14-5 2,6-dichloropyrazine 

Relevant articles and documents

Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof

The invention relates to substituted 1-piperazinylacylpiperidine derivatives of general formula (I) in which: n is 1 or 2; p is 1 or 2; R1 represents a halogen atom; a trifluoromethyl radical; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethoxy radical; R2 represents a hydrogen atom or a halogen atom; R3 represents a hydrogen atom; a group —OR5; a group —CH2OR5; a group —NR6R7; a group —NR8COR9; a group —NR8CONR10R11; a group —CH2NR12R13; a group —CH2NR8CONR14R15; a (C1-C4)alkoxycarbonyl; a group —CONR16R17; or else R3 constitutes a double bond between the carbon atom to which it is attached and the adjacent carbon atom of the piperidine ring; R4 represents an aromatic group selected from: the said aromatic groups being unsubstituted or being mono- or disubstituted by a substituent selected independently from a halogen atom; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethyl radical; Preparation process and therapeutic application.

1,2,4-TRIAZOL-3-ONE ANTIDEPRESSANTS

Phenoxyalkyl substituted-1,2,4-triazolones having anti-depressant properties typified by 2-3-4-(3-chlorophenyl)-1-piperazinyl!propyl!-5-ethyl-4-(2-phenoxyethyl)-2H-1,2, 4-triazol-3(4H)-one are disclosed.

6-Chloro-2-(1-piperazinyl)pyrazine

The compound 6-chloro-2-(1'-piperazinyl)pyrazine, its N-oxides and acid-addition salts are disclosed having pharmacological activity as anorexic agents.