426829-52-9

Basic information

• Product Name: 6'-CHLORO-2,3,5,6-TETRAHYDRO-[1,2']BIPYRAZINYL-4-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 6'-CHLORO-2,3,5,6-TETRAHYDRO-[1,2']BIPYRAZINYL-4-CARBOXYLIC ACID TERT-BUTYL ESTER;TERT-BUTYL 4-(6-CHLOROPYRAZIN-2-YL)PIPERAZINE-1-CARBOXYLATE;1-N-Boc-4-(6-chloropyrazin-2-yl)piperazine;6'-Chloro-2;1-Piperazinecarboxylicacid, 4-(6-chloro-2-pyrazinyl)-, 1,1-dimethylethyl ester
• CAS NO: 426829-52-9
• Molecular Formula: C₁₃H₁₉ClN₄O₂
• Molecular Weight: 298.77
• Mol File: 426829-52-9.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6'-CHLORO-2,3,5,6-TETRAHYDRO-[1,2']BIPYRAZINYL-4-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 6'-CHLORO-2,3,5,6-TETRAHYDRO-[1,2']BIPYRAZINYL-4-CARBOXYLIC ACID TERT-BUTYL ESTER(426829-52-9)
• EPA Substance Registry System: 6'-CHLORO-2,3,5,6-TETRAHYDRO-[1,2']BIPYRAZINYL-4-CARBOXYLIC ACID TERT-BUTYL ESTER(426829-52-9)

Safety Data

• Hazardous Substances Data: 426829-52-9(Hazardous Substances Data)

Usage

Uses

6''-Chloro-2,3,5,6-tetrahydro-[1,2'']bipyrazinyl-4-carboxylic Acid tert-Butyl Ester

Upstream product

• 4774-14-5 2,6-dichloropyrazine 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 2402-78-0 2,6-dichloropyridine 
• 19745-07-4 2,5-dichloropyrazine 

Downstream Products

• 1143578-07-7 tert-butyl 4-(6-phenylpyrazin-2-yl)piperazine-1-carboxylate 
• 1143577-29-0 tert-butyl 4-[6-(2,4-difluorophenyl)pyrazin-2-yl]piperazine-1-carboxylate 
• 1147998-23-9 tert-butyl 4-{6-[5-(1-methyl-1H-pyrazol-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrazin-2-yl}piperazine-1-carboxylate 
• 61655-58-1 2-chloro-6-(1-piperazinyl)pyrazine monohydrochloride 
• 64022-27-1 6-chloro-2-(1-piperazinyl)pyrazine 

Relevant articles and documents

Methylpyrazole derivatives as RET inhibitor

The invention relates to a methylpyrazole derivative as an RET inhibitor, in particular to a compound as shown in a formula (I), a stereoisomer and pharmaceutically acceptable salt thereof, a preparation method and a pharmaceutical composition thereof. The compound of the formula (I) can be used for preventing or treating diseases mediated by abnormal RET activity.

NOVEL NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND

A compound represented by general formula [1] wherein X represents N or the like, Y represents CH or the like; RA represents a cycloalkyl group which may be substituted or the like, R1 represents an alkyl group or the like, R2 represents an alkyl group which may be substituted or the like, R3 represents a hydrogen atom or an alkyl group, or a pharmaceutically acceptable salt thereof has an inhibitory activity on aldosterone synthetase, and is useful as a prophylactic and/or therapeutic agent for various diseases or symptoms associated with aldosterone.

Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases

A series of novel 3,5-disubstituted indole derivatives as potent and selective inhibitors of all three members of the Pim kinase family is described. High throughput screen identified a pan-Pim kinase inhibitor with a promiscuous scaffold. Guided by struc