61657-67-8 Usage
Uses
Used in Pharmaceutical Synthesis:
3,5-DIBROMO-2-ETHOXYBENZALDEHYDE is utilized as an intermediate in the production of various pharmaceuticals. Its unique chemical structure allows it to be a key component in the synthesis of drugs, contributing to the development of new medications.
Used in Agrochemical Production:
In the agrochemical industry, 3,5-DIBROMO-2-ETHOXYBENZALDEHYDE serves as an intermediate, playing a crucial role in the creation of pesticides and other agricultural chemicals. Its properties make it valuable for enhancing crop protection and management strategies.
Used as a Corrosion Inhibitor in Metalworking Fluids:
3,5-DIBROMO-2-ETHOXYBENZALDEHYDE has been studied for its potential as a corrosion inhibitor in metalworking fluids. Its application helps to prevent the degradation of metal surfaces during manufacturing processes, thereby extending the life of machinery and improving the quality of the end products.
Check Digit Verification of cas no
The CAS Registry Mumber 61657-67-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,6,5 and 7 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 61657-67:
(7*6)+(6*1)+(5*6)+(4*5)+(3*7)+(2*6)+(1*7)=138
138 % 10 = 8
So 61657-67-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H8Br2O2/c1-2-13-9-6(5-12)3-7(10)4-8(9)11/h3-5H,2H2,1H3
61657-67-8Relevant academic research and scientific papers
Optimization of a binding fragment targeting the “enlarged methionine pocket” leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors
Huang, Wenlin,Zhang, Zhongsheng,Ranade, Ranae M.,Gillespie, J. Robert,Barros-álvarez, Ximena,Creason, Sharon A.,Shibata, Sayaka,Verlinde, Christophe L.M.J.,Hol, Wim G.J.,Buckner, Frederick S.,Fan, Erkang
supporting information, p. 2702 - 2707 (2017/05/29)
Potent inhibitors of Trypanosoma brucei methionyl-tRNA synthetase were previously designed using a structure-guided approach. Compounds 1 and 2 were the most active compounds in the cyclic and linear linker series, respectively. To further improve cellular potency, SAR investigation of a binding fragment targeting the “enlarged methionine pocket” (EMP) was performed. The optimization led to the identification of a 6,8-dichloro-tetrahydroquinoline ring as a favorable fragment to bind the EMP. Replacement of 3,5-dichloro-benzyl group (the EMP binding fragment) of inhibitor 2 using this tetrahydroquinoline fragment resulted in compound 13, that exhibited an EC50 of 4?nM.
