616867-70-0Relevant academic research and scientific papers
Rapid assembly of diverse and potent allosteric Akt inhibitors
Wu, Zhicai,Robinson, Ronald G.,Fu, Sheng,Barnett, Stanley F.,Defeo-Jones, Deborah,Jones, Raymond E.,Kral, Astrid M.,Huber, Hans E.,Kohl, Nancy E.,Hartman, George D.,Bilodeau, Mark T.
, p. 2211 - 2214 (2008/09/21)
This paper describes the rapid assembly of four different classes of potent Akt inhibitors from a common intermediate. Among them, a pyridopyrimidine series displayed the best intrinsic and cell potency against Akt1 and Akt2. This series also showed a pro
