616870-20-3Relevant academic research and scientific papers
Allosteric inhibitors of Akt1 and Akt2: A naphthyridinone with efficacy in an A2780 tumor xenograft model
Bilodeau, Mark T.,Balitza, Adrienne E.,Hoffman, Jacob M.,Manley, Peter J.,Barnett, Stanley F.,Defeo-Jones, Deborah,Haskell, Kathleen,Jones, Raymond E.,Leander, Karen,Robinson, Ronald G.,Smith, Anthony M.,Huber, Hans E.,Hartman, George D.
scheme or table, p. 3178 - 3182 (2009/04/11)
A series of naphthyridine and naphthyridinone allosteric dual inhibitors of Akt1 and 2 have been developed. These compounds have been optimized to have potent dual activity against the activated kinase as well as the activation of Akt in cells. One molecu
