33760-73-5Relevant academic research and scientific papers
A Simple “Green” Synthesis of Novel Bis(3-aryl-1,8-naphthyridin-2-yl)sulfanes and 2-(Methylthio)-3-aryl-1,8-naphthyridines under Microwave Irradiation and Conventional Conditions
Ravi,Ashok,Rambabu,Sakram,Shyam
, p. 1232 - 1237 (2018/08/16)
An eco-friendly and highly efficient synthesis of substituted bis(3-aryl-1,8-naphthyridin-2-yl)-sulfanes and 2-(methylthio)-3-aryl-1,8-naphthyridines under microwave and conventional conditions. The products are obtained with high yields and purity within short reaction time. The synthesized derivatives are screened for anti-microbial activity against bacteria and fungi. Molecular docking of the synthesized compounds with DNA Gyrase is studied.
An Exceedingly Mild, Green Synthesis of Substituted N-3-diaryl-1,8-naphthyridin-2-amine Derivatives and Their Antimicrobial Activity
Ravi, Dharavath,Rambabu, Sirgamalla,Ashok, Kommakula,Madhu, Palithapu,Sakram, Boda
, p. 957 - 963 (2018/02/26)
An exceedingly and highly efficient procedure has been described for the synthesis of substituted N-3-diaryl-1,8-naphthyridin-2-amines by the reaction of 2-chloro-3-aryl-1,8-naphthyridines with various anilines in the presence of N-methyl-2-pyrrolidone and K2CO3 under thermal green solvent-free conditions. The significant features of this green reaction include very good yields in purity, simple experimental, short reaction time, easy workability, and avoidance of toxic solvents. All synthesized compounds have been evaluated for their antibacterial activity.
An Efficient Microwave-Assisted Synthesis of Novel 2-{4-[(3-Aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones and Their Antimicrobial Activity
Sakram,Ravi,Ashok,Rambabu,Sonyanaik,Kurumanna
, p. 780 - 788 (2018/06/14)
The Buchwald–Hartwig amination reaction between 2-chloro-3-aryl-1,8-naphthyridines and 2-(4-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione in the presence of the catalytic system Pd(PPh3)4 and the base KO-t-Bu in toluene was studied. The reaction was initiated by microwave irradiation. Highly efficient synthesis has been developed for 2-{4-[(3-aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones. Structures of the synthesized compounds were evaluated by IR, 1H and 13C NMR spectroscopy. All products were tested for antimicrobial activity against Escheria coli, Bacillus subtilis, Klebsiella pneumoniae, and Staphylococcus aureus.
Allosteric inhibitors of Akt1 and Akt2: A naphthyridinone with efficacy in an A2780 tumor xenograft model
Bilodeau, Mark T.,Balitza, Adrienne E.,Hoffman, Jacob M.,Manley, Peter J.,Barnett, Stanley F.,Defeo-Jones, Deborah,Haskell, Kathleen,Jones, Raymond E.,Leander, Karen,Robinson, Ronald G.,Smith, Anthony M.,Huber, Hans E.,Hartman, George D.
scheme or table, p. 3178 - 3182 (2009/04/11)
A series of naphthyridine and naphthyridinone allosteric dual inhibitors of Akt1 and 2 have been developed. These compounds have been optimized to have potent dual activity against the activated kinase as well as the activation of Akt in cells. One molecu
Synthesis of 1,2,4-triazolo[4,3-a] [1,8]naphthyridines
Shailaja Rani,Mogilaiah,Sreenivasulu
, p. 106 - 110 (2007/10/03)
2-Hydroxy-3-phenyl-1,8-naphthyridine (2) on treatment with POCl3 gives 2-chloro-3-phenyl-1,8-naphthyridine (3) which on hydrazinolysis yields 2-hydrazino-3-phenyl-1,8-naphthyridine (4). The hydrazine 4 on condensation with aromatic aldehydes in ethanol containing a catalytic amount of gl. acetic acid affords 3-phenyl-1,8-naphthyridin-2-yl hydrazones (5), which on oxidative cyclization with nitrobenzene under reflux results in the formation of 1-aryl-4-phenyl-1,2,4-triazolo[4,3-a][1,8]naphthyridines (6). Further, 4 when treated with formic acid and gl. acetic acid yields the respective 1,2,4-triazolo[4,3-a][1,8]naphthyridines (7 and 8). The structures of the compounds 3-8 have been established on the basis of their elemental analyses and spectral (IR, 1H NMR and mass) data and are evaluated for their antimicrobial activities.
Synthesis of 2-(3-aryl-4-formylpyrazol-1-yl)-3-phenyl-1,8-naphthyridines
Rao, J. Sudhakar,Mogilaiah,Sreenivasulu
, p. 713 - 714 (2007/10/03)
2-(3-Aryl-4-formylpyrazol-1-yl)-3-phenyl-1,8-naphthyridines (3) have been synthesized by the reaction of acetophenone 3-phenyl-1,8-naphthyridin-2-ylhydrazones (2) with POCl3 and DMF. The intermediate hydrazones 2 in turn are prepared by the con
