616876-52-9

Upstream product

• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 635288-14-1 methyl (dimethylthexylsilyl 4-O-(2-azido-3,4-di-O-benzyl-2-deoxy-α-D-glucopyranosyl)-3-O-benzyl-2-O-benzoyl-β-L-idopyranosyl)uronate 
• 98-88-4 benzoyl chloride 
• 243982-79-8 methyl (dimethylthexylsilyl 3-O-benzyl-β-L-idopyranoside)uronate 
• 635288-05-0 methyl (dimethylthexylsilyl-4-O-(2-azido-3-O-benzyl-4,6-O-benzylidene-α-D-glucopyranosyl)-3-O-benzyl-2-O-benzoyl-L-β-idopyranosyl)uronate 
• 382614-17-7 methyl [dimethylthexylsilyl 4-O-(2-azido-3-O-benzyl-4,6-O-benzylidene-2-deoxy-α-D-glucopyranosyl)-3-O-benzyl-β-L-idopyranoside]uronate 

Relevant academic research and scientific papers

Synthesis and structural study of two new heparin-like hexasaccharides.

Two new heparin-like hexasaccharides, 5 and 6, have been synthesised using a convergent block strategy and their solution conformations have been determined by NMR spectroscopy and molecular modelling. Both hexasaccharides contain the basic structural motif of the regular region of heparin but with negative charge distributions which have been designed to get insight into the mechanism of fibroblast growth factors (FGFs) activation.

Some key experimental features of a modular synthesis of heparin-like oligosaccharides

The key features of a modular n+2 strategy for a completely stereoselective synthesis of oligosaccharides containing the GlcN-IdoA repeating unit of the major sequence of heparin are presented and discussed in detail. These key features include the regio-