616885-87-1Relevant academic research and scientific papers
2, 5-Bis-Diamine [1,4] Benzoquinone-Derivatives
-
Page/Page column 13, (2009/04/24)
Synthesis of 2,5-bis-diamine-[1,4]benzoquinonic derivatives having the general formula (I), products and intermediates of said synthesis; the synthesis involves the use of p-benzoquinones having the general formula (IX) and diamines having the general for
Synthesis of 2,5-Diaminoquinones by one-pot copper-catalyzed aerobic oxidation of hydroquinones and addition reaction of amines
Kim, Sungjin,Kim, Daehwan,Park, Jaiwook
experimental part, p. 2573 - 2578 (2009/12/29)
The aerobic oxidation of various hydroquinones was achieved by using copper nanoparticles entrapped in aluminum oxyhydroxide [Cu/ AlO(OH)] at room temperature. Furthermore, 2,5diamino-1,4-benzoquinones were synthesized directly from hydroquinone and amines by a one-pot procedure consisting of the copper-catalyzed aerobic oxidation of hydroquinones and the double addition of amines to the resulting quinones.
A small molecule targeting the multifactorial nature of Alzheimer's disease
Cavalli, Andrea,Bolognesi, Maria Laura,Capsoni, Simona,Andrisano, Vincenza,Bartolini, Manuela,Margotti, Elisa,Cattaneo, Antonino,Recanatini, Maurizio,Melchiorre, Carlo
, p. 3689 - 3692 (2008/03/12)
(Figure Presented) Sights set on a cure: Memoquin (1) affects several mechanisms relevant to Alzheimer's disease (AD): the formation of reactive oxygen species, the processing and aggregation of amyloid β (Aβ) peptides, and acetylcholinesterase activity.
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease
Bolognesi, Maria Laura,Banzi, Rita,Bartolini, Manuela,Cavalli, Andrea,Tarozzi, Andrea,Andrisano, Vincenza,Minarini, Anna,Rosini, Michela,Tumiatti, Vincenzo,Bergamini, Christian,Fato, Romana,Lenaz, Giorgio,Hrelia, Patrizia,Cattaneo, Antonino,Recanatini, Maurizio,Melchiorre, Carlo
, p. 4882 - 4897 (2008/03/11)
One of the characteristics of Alzheimer's disease (AD) that hinders the discovery of effective disease-modifying therapies is the multifactorial nature of its etiopathology. To circumvent this drawback, the use of multi-target-directed ligands (MTDLs) has
Useful for treating neuropraxia Alzheimer 2, 5-BIS-Dimamine-[ 1, 4] Benzoquinonimine derivative, and a method for manufacturing the same, and a method for manufacturing the intermediate body
-
Page/Page column 17-18, (2008/06/13)
2,5-bis-diamine-[1,4]benzoquinonic derivatives, having a general formula (I) have proved useful for the treatment of Alzheimer's disease; a method for preparing them and intermediates used in said method are also described.
