61698-78-0Relevant academic research and scientific papers
1,1-Dianisyl-2,2,2-trichloroethyl ethers - A new protection for the hydroxyl group
Karl,Kloesel, Rosa Maria KarlRoland,Klosel,Koenig, Stephan,Konig,Lehnhoff, Stefan,Lehnhoff,Ugi, Ivar,Ugi
, p. 3759 - 3766 (2007/10/02)
β-Haloalkyl protecting groups are well established. However, there was a lack of an appropriate protection, especially for carboxyl and vicinal hydroxyl groups. This problem was now solved by design of the 1,1-dianisyl-2,2,2-trichloroethyl group (DATE). The alkylation of model alcohols with the DATE moiety is described. The resulting β-haloalkyl ethers proved to be remarkable stable against acids and bases. Deblocking of the model alcohols is achieved in high yields.
