61700-67-2Relevant academic research and scientific papers
N-Isocyanodialkylamines generated in situ for the Joullié–Ugi reaction with indolenines
Golubev, Pavel,Krasavin, Mikhail
supporting information, p. 3532 - 3536 (2018/08/29)
N-Isocyanodialkylamines are rare isocyanide surrogates for the Ugi-type reactions. To avoid problems with instability and the obnoxious smell of these reagents, we optimized and employed a convenient protocol for in situ dehydration of N,N-dialkyl-N′-formyl hydrazines to give the respective N-isocyanodialkylamines which were utilized in the reaction with indolenines and acetic acid. The reaction was demonstrated to give modest to excellent yields of products incorporating the N-isocyanodialkylamine but not the carboxylic acid component.
