61712-13-8Relevant academic research and scientific papers
Iron-catalyzed stereospecific arylation of enol tosylates using Grignard reagents
Wei, Yi-Ming,Ma, Xiao-Di,Wang, Lei,Duan, Xin-Fang
supporting information, p. 1101 - 1104 (2020/02/04)
The stereospecific Fe-catalyzed arylation of enol tosylates was reported. Various tri- or tetrasubstituted Z or E-enol tosylates of β-keto esters were arylated using common and Knochel-type Grignard reagents with complete stereofidelity. The precursors fo
Dynamic Kinetic Resolution of Alkenyl Cyanohydrins Derived from α,β-Unsaturated Aldehydes: Stereoselective Synthesis of E-Tetrasubstituted Olefins
Majhi, Jadab,Turnbull, Ben W. H.,Ryu, Ho,Park, Jiyong,Baik, Mu-Hyun,Evans, P. Andrew
supporting information, p. 11770 - 11774 (2019/08/16)
A novel dynamic kinetic resolution (DKR) of tetrasubstituted alkenyl cyanohydrins prepared from the corresponding α,β-unsaturated aldehydes is described. The deprotonation of a geometrical mixture of tetrasubstituted alkenyl cyanohydrins with sodium diiso
(E)- and (Z)-stereodefined enol phosphonates derived from β-ketoesters: Stereocomplementary synthesis of fully-substituted α,β-unsaturated esters
Nakatsuji, Hidefumi,Ashida, Yuichiro,Hori, Hiroshi,Sato, Yuka,Honda, Atsushi,Taira, Mayu,Tanabe, Yoo
, p. 8205 - 8210 (2015/08/03)
A versatile, robust, and stereocomplementary synthesis of fully-substituted (E)- and (Z)-stereodefined α,β-unsaturated esters 3 from accessible α-substituted β-ketoesters 1via (E)- and (Z)-enol phosphonates was achieved. The present method involves two ac
Tandem Blaise/retro-Blaise reaction for the nitrile-mediated regioselective intermolecular addition of unstabilized zinc ester enolates (Reformatsky Reagents) to 1-alkynes and 1,3-enynes
Kim, Ju Hyun,Chun, Yu Sung,Lee, Sang-Gi
, p. 11483 - 11493 (2013/12/04)
We report the novel use of a nitrile as a mediator to achieve the regioselective intermolecular addition of unstabilized zinc ester enolates (Reformatsky reagents) to 1-alkynes and 1,3-enynes. This reaction is made possible by a reversible addition of enolates to a nitrile (Blaise reaction), generating a zinc aza-enolate that, unlike zinc ester enolates, can add intermolecularly to 1-alkynes and 1,3-enynes. Subsequent removal of the nitrile through a retro-Blaise reaction generates the targeted addition product. This method is combined with a Diels-Alder reaction and subsequent oxidative aromatization, providing a tandem one-pot de novo construction of α-arylated alkanoates from Reformatsky reagents.
ARYL SULFAMATE DERIVATIVES
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Page 40, (2010/02/07)
The present invention provides an aryl sulfamate derivative represented by Formula (I) (wherein Rr and Rs, which may be the same or different, each represent a hydrogen atom or lower alkyl, R1, R2, R3
Palladium-Catalyzed Highly Regio- and Stereoselective Addition of Organoboronic Acids to Allenes in the Presence of AcOH
Ma, Shengming,Jiao, Ning,Ye, Longwu
, p. 6049 - 6056 (2007/10/03)
The Pd0-catalyzed regio- and stereoselective addition of organoboronic acids to allenes leads to stereodefined tri- or tetrasubstituted alkenes. Furthermore, this method shows high substitutent-loading capability and tolerance of various substitutents. A hydropalladation-Suzuki coupling mechanism, which may account for the regio- and stereoselectivity, is proposed.
SYNTHESIS, MOLECULAR PROPERTIES AND PHARMACOLOGICAL ACTIVITY OF SOME p-SUBSTITUTED (E)- AND (Z)-α,β-DIMETHYLCINNAMIC ACIDS
Balsamo, Aldo,Crotti, Paolo,Macchia, Bruno,Macchia, Franco,Martinelli, Adriano,et al.
, p. 327 - 332 (2007/10/02)
A series of p-substituted (E)- and (Z)-α,β-dimethylcinnamic acids has been prepared and pharmacologically tested.The configurations of the acids prepared were determined from their NMR spectra.The UV spectra and the acid dissociation constants are reported.The collected data show that an extensive conjugation between the aryl and carboxy groups via the double bond does not exist, due to the steric hindrance of the α,β-dimethyl substitution on the cinnamic system.
