61712-17-2

Upstream product

• 108062-63-1 2-methyl-3-p-tolyl-crotonic acid ethyl ester 
• 61712-26-3 (Z)-4,α,β-Trimethylzimtsaeure 
• 27835-00-3 ethyl (4-methylbenzoyl)acetate 
• 52884-48-7 2-methyl-3-(p-methylphenyl)-3-oxopropionic acid ethyl ester 
• 1643935-43-6 C₁₄H₁₅F₃O₅S 
• 61712-12-7 ethyl (2E)-2-methyl-3-(4-methylphenyl)but-2-enoate 
• 64-18-6 formic acid 
• 61746-89-2 3-hydroxy-2-methyl-3-p-tolyl-butyric acid ethyl ester 

Downstream Products

• 105401-60-3 2-methyl-3-(p-tolyl)butanoic acid 
• 61712-26-3 (Z)-4,α,β-Trimethylzimtsaeure 
• 1643935-67-4 (2E,5E)-phenyl 3-(benzhydryloxy)-2,5-dimethyl-4-oxo-6-(p-tolyl)hepta-2,5-dienoate 
• 1643935-82-3 (1S,2S)-phenyl 4-hydroxy-1,2,3-trimethyl-5-oxo-2-(p-tolyl)cyclopent-3-enecarboxylate 

Relevant academic research and scientific papers

Catalytic enantioselective nazarov cyclization: Construction of vicinal all-carbon-atom quaternary stereocenters

The diastereoselective asymmetric synthesis of vicinal all-carbon-atom quaternary stereocenters is a challenging problem in organic synthesis for which only few solutions have been described. A catalytic asymmetric Nazarov cyclization of fully substituted dienones that provides cyclopentenone derivatives with vicinal quaternary stereocenters in high optical purity and as single diastereoisomers is now reported.

SYNTHESIS, MOLECULAR PROPERTIES AND PHARMACOLOGICAL ACTIVITY OF SOME p-SUBSTITUTED (E)- AND (Z)-α,β-DIMETHYLCINNAMIC ACIDS

A series of p-substituted (E)- and (Z)-α,β-dimethylcinnamic acids has been prepared and pharmacologically tested.The configurations of the acids prepared were determined from their NMR spectra.The UV spectra and the acid dissociation constants are reported.The collected data show that an extensive conjugation between the aryl and carboxy groups via the double bond does not exist, due to the steric hindrance of the α,β-dimethyl substitution on the cinnamic system.