61713-41-5

Usage

Also known as

4-Chloro-3-benzylacetylacetone

Physical state

Yellowish solid

Applications

Pharmaceutical intermediate, reagent in organic synthesis

Pharmaceutical industry uses

Synthesis of chiral drugs and biologically active compounds

Properties

Useful building block in pharmaceutical and organic compound development

Studied properties

Potential anticancer and antiviral properties

Importance

Target for further research and development in medicinal chemistry.

Upstream product

• 622-95-7 4-chlorobenzyl bromide 
• 123-54-6 acetylacetone 
• 71017-85-1 1-(4-chlorobenzyl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate 
• 19411-75-7 3-(4-chlorobenzylidene)pentane-2,4-dione 

Downstream Products

• 932707-00-1 8-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-ol 
• 932707-28-3 5-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-7-ol 
• 932707-08-9 3-(4-chlorobenzyl)-2,4,7-trimethylquinolin-5-ol 

Relevant academic research and scientific papers

FeCl3·6H2O-catalyzed selective conjugate reduction of alkylidene-β-keto esters and alkylidene-1,3-diketones

FeCl3·6H2O/triethylsilane composite catalyst system is successfully developed for the selective conjugate reduction of carbon-carbon double bond of Michael acceptor-alkylidene-β-keto esters and alkylidene-1,3-diketones under mild rea

C-ALKYLATION OF β-DIKETONES WITH BENZYLPYRIDINIUM SALTS. EVIDENCE FOR CHAIN RADICAL MECHANISMS

1-(p-Substituted benzyl)-2,4,6-triphenylpyridinium cations react with β-diketone anions by mechanisms which depend on the para-substituent.The p-methoxybenzyl derivative undergoes SN1 displacement yielding O- and C-benzylated products.The p-nitrobenzyl compound reacts by a chain radicaloid mechanism and gives high yields of C-p-nitrobenzylated diketones.The parent benzyl compound forms some C- and some O-benzylated products, together with bibenzyl, probably by a radical chain reaction which was suppressed by radical traps.