932707-08-9

Basic information

• Product Name: 3-(4-chlorobenzyl)-2,4,7-trimethylquinolin-5-ol
• Synonyms: 3-(4-chlorobenzyl)-2,4,7-trimethylquinolin-5-ol
• CAS NO: 932707-08-9
• Molecular Weight: 311.811
• Mol File: 932707-08-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-chlorobenzyl)-2,4,7-trimethylquinolin-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorobenzyl)-2,4,7-trimethylquinolin-5-ol(932707-08-9)
• EPA Substance Registry System: 3-(4-chlorobenzyl)-2,4,7-trimethylquinolin-5-ol(932707-08-9)

Safety Data

• Hazardous Substances Data: 932707-08-9(Hazardous Substances Data)

Upstream product

• 61713-41-5 3-(4-chlorobenzyl)pentane-2,4-dione 
• 76619-89-1 3-amino-5-methylphenol 

Downstream Products

• 932707-10-3 trifluoromethanesulfonic acid 3-(4-chlorobenzyl)-2,4,7-trimethylquinolin-5-yl ester 
• 932707-07-8 [3-(4-chlorobenzyl)-2,4,7-trimethylquinolin-5-yloxy]acetic acid methyl ester 

Relevant articles and documents

QUINOLINES AND THEIR THERAPEUTIC USE

Compounds of formula [1] are CRTH2 antagonists, useful in the treatment of conditions having an inflammatory component; in which: R1, R2, R3, R4 and R5 are independently hydrogen, C1-C6alkyl, C1- C6fluoroalkyl, cyclopropyl, halo, -S(O)nR6, -SO2NR7R8, -NR7R8, -NR7C(O)R6, -CO2R7, -C(O)NR7R8, -C(O)R6, -NO2, -CN or a group -OR9; wherein each R6 is independently C1-C6alkyl, C1-C6fluoroalkyl, cycloalkyl, aryl, or heteroaryl; R7, R8 are independently C1-C6alkyl, C1-C6fluoroalkyl, cycloalkyl, cycloalkyl-(C1-C6alkyl)-, aryl, heteroaryl or hydrogen; R9 is hydrogen, C1-C6alkyl, C1-C6fluoroalkyl, cycloalkyl, cylcoalkyl-(C1-C6alkyl)-, or a group -SO2R6; A is -CHR10-, -C(O)-, -S(O)n-, -0-, or -NR10- wherein n is an integer from 0-2 and R10 is hydrogen, C1-C3alkyl, or C1-C6fluoroalkyl group; B is a direct bond, or a divalent radical selected from -CH2-, -CH2CH2-, -CHR11-, -CR11R12-, -CH2CHR11-, -CH2CR11R12-, -CHR11CHR12-, and divalent radicals of formula -(CR11R12)P-Z- wherein Z is attached to the ring carrying R1, R2 and R3; wherein R11 is C1-C3alkyl, cyclopropyl, C1-C6fluoroalkyl; R12 is methyl or fluoromethyl; p is independently 1 or 2; and Z is -0-, -NH-, or -S(O)n-, wherein n is an integer from 0-2; X is a carboxylic acid, tetrazole, 3-hydroxyisoxazole, hydroxamic acid, phosphinate, phosphonate, phosphonamide, or sulfonic acid group, or a group of formula C(=O)NHSO2R6or SO2NHC(=O)R6; and Y is aryl, heteroaryl, aryl-fused- heterocycloalkyl, heteroaryl-fused-cycloalkyl, heteroaryl-fused-heterocycloalkyl or aryl-fused-cycloalkyl group.