6172-80-1

Upstream product

• 18108-09-3 butyl hypophosphite 
• 74-88-4 methyl iodide 

Downstream Products

• 15536-25-1 Methylphosphonsaeure-butylester-mercaptobutylester 
• 95886-02-5 (4-Chloro-phenyl)-methyl-phosphinic acid butyl ester 
• 51103-74-3 n-butyl methyl-phenylphosphinate 
• 104855-58-5 Methyl-((E)-styryl)-phosphinic acid butyl ester 
• 95886-00-3 methyl-p-tolyl-phosphinic acid butyl ester 
• 95886-01-4 Methyl-o-tolyl-phosphinic acid butyl ester 
• 104855-59-6 Methyl-(1-phenyl-vinyl)-phosphinic acid butyl ester 
• 95885-68-0 (4-Cyano-phenyl)-methyl-phosphinic acid butyl ester 
• 95885-66-8 (4-Methoxycarbonylamino-phenyl)-methyl-phosphinic acid butyl ester 
• 95885-67-9 (4-Dimethylamino-phenyl)-methyl-phosphinic acid butyl ester 
• 95885-64-6 Methyl-(4-nitro-phenyl)-phosphinic acid butyl ester 
• 1397293-76-3 butyl [(2-ethoxycarbonyl)phenyl]methylphosphinate 
• 172529-93-0 3-[n-butoxy(methyl)phosphoryl]-1-cyanopropyl acetate 
• 95885-65-7 (4-Acetyl-phenyl)-methyl-phosphinic acid butyl ester 

Relevant academic research and scientific papers

DBU-promoted alkylation of alkyl phosphinates and H-phosphonates

The alkylation of alkyl phosphinates and some H-phosphonate diesters is promoted by the base DBU. Only more reactive alkyl halides react in preparatively useful yields. However, the method provides easy access to important H-phosphinate building blocks, without the need for a protecting group strategy or metal catalysts. The reaction is conveniently conducted at, or below, room temperature. The preparation of methyl-H-phosphinate esters is particularly interesting as it avoids the heretofore more common use of methyldichlorophosphine MePCl2.