Modifications of primaquine as antimalarials. 3. 5-Phenoxy derivatives of primaquine

Article abstract of DOI:10.1021/jm00351a018

Various 5-phenoxy derivatives of primaquine have been prepared that are somewhat more effective and considerably less toxic that the parent compound in blood and tissue schizonticidal screens. Addition of a methyl group to the pyridine ring of the 5-phenoxyprimaquines has produced a number of antimalarials with potent activity against both blood and tissue schizonts.