61735-52-2

Usage

Chemical Class

Naphthalenes (aromatic hydrocarbons)

Physical State

White solid

Solubility

Insoluble in water, soluble in organic solvents

Primary Use

Intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes

Secondary Use

Building block in the production of other chemicals

Safety Precautions

Wear protective clothing and work in a well-ventilated area due to potential mutagenicity and irritancy.

Upstream product

• 83-55-6 5-amino-1-naphthol 
• 6271-81-4 5-methoxynaphthalen-1-ylamine 
• 3698-28-0 2-allylanisole 
• 91498-80-5 8-Chloro-4-methoxy-naphthalene-2-carboxylic acid 

Downstream Products

• 1446746-10-6 8-chloro-N,N-dimethyl-4-((2-methyl-3-(trifluoromethyl)phenyl)amino)-1-naphthamide 
• 20816-76-6 5-chloro-1-naphthalenol 

Relevant academic research and scientific papers

A Visible Light and Iron-mediated Carbocationic Route to Polysubstituted 1-Halonaphthalenes by Benzannulation using Allylbenzenes and Polyhalomethanes

A wide array of polysubstituted 1-bromo and chloronaphthalenes are obtained from coupling of allylbenzenes and polyhalomethanes. The reaction is mediated by iron metal under visible light irradiation and proceeds via a Kharasch addition intermediate followed by intramolecular FeIII mediated Friedel-Crafts alkylation, with the formation of two Csp2?Csp2 bonds in the process. This method gives easy access to 1-halonaphthalenes with substituent(s) at C-5 to C-8 that are otherwise hard to synthesize. (Figure presented.).

CANNABINOID RECEPTOR MODULATORS

Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors of Formula (I).

CANNABINOID RECEPTOR MODULATORS

Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors of Formula (I).