6175-42-4

Usage

Chemical structure

A compound with three benzene rings and a thiourea functional group.

Derivative

It is a derivative of thiourea.

Substituents

Contains substituents of 4-bromobenzyl, 4-methoxybenzyl, and 3-methoxyphenyl.

Potential applications

Has potential biological and pharmaceutical applications due to its ability to interact with biological systems and potentially exhibit therapeutic effects.

Drug development

May be used in the development of new drugs.

Research tool

Can be used as a research tool in the study of molecular interactions within cells.

Chemical synthesis

Its unique structure and properties make it a valuable compound for chemical synthesis.

Organic chemistry research

Useful for analysis in organic chemistry research.

Upstream product

• 131-11-3 phthalic acid dimethyl ester 
• 107-87-9 2-Pentanone 
• 84-66-2 Diethyl phthalate 
• 609-67-6 2-Iodobenzoyl chloride 
• 88-67-5 2-Iodobenzoic acid 
• 1864-94-4 phenyl formate 

Relevant academic research and scientific papers

Convenient synthesis, anticancer evaluation and QSAR studies of some thiazole tethered indenopyrazoles

Abstract: A convenient one-pot synthesis of twelve new thiazole tethered indeno[1,2-c]pyrazol-4-ones (3a–3l) was carried out by three-component reaction between 1,3-diketones, thiosemicarbazide and α-bromoketones in high yields. Wolff-Kishner reduction of indeno[1,2-c]pyrazol-4-ones (3a–3l) led to the formation of corresponding indeno[1,2-c]pyrazoles (4a–4l) in moderate-to-good yields. The structures of all the synthesized indenopyrazoles were elucidated by IR, 1H NMR, 13C NMR and mass spectral techniques. In vitro cytotoxicity of thiazole tethered indenopyrazoles (3a–3l & 4a–4l) was evaluated against different human cancer cell lines, viz. human renal carcinoma (A498), human colorectal adenocarcinoma (HT29), human breast adenocarcinoma (MCF-7), human hepatocellular carcinoma (HepG2) and normal cell line, i.e., normal rat kidney epithelial (NRK). Among all the tested derivatives, 4a, 4d and 4h exhibited better activity against HT29 cancer cell line. The statistically significant QSAR models were developed for all the cancer cell lines using multiple linear regression analysis to understand the observed activity trend on structural basis. Graphical Abstract: [Figure not available: see fulltext.]

Palladium-Catalyzed Carbonylative Annulation Reactions Using Aryl Formate as a CO Source: Synthesis of 2-Substituted Indene-1,3(2H)-dione Derivatives

An efficient synthesis of 2-substituted indene-1,3(2H)-diones from stable and readily available 1-(2-halophenyl)-1,3-diones by employing phenyl formate as a CO source has been developed. The reaction occurred via palladium-catalyzed intramolecular carbonylative annulation using K3PO4 as a base and DMSO as a solvent at 95 °C. In this protocol, the reaction showed a broad substrate scope with good to excellent yields.